Oncogenes and Tumor Suppressor Genes

Two of the main types of genes that play a role in cancer are oncogenes and tumour suppressor genes.

Oncogenes

Proto-oncogenes are genes that normally help cells grow. When a proto-oncogene mutates (changes) or there are too many copies of it, it becomes a “bad” gene that can turn on permanently when it’s not supposed to be. When this happens, the cell grows out of control, which can lead to cancer. This bad gene is called an oncogene.

It can be helpful to think of a cell as a car. For it to work properly, there must be ways to control how fast it goes. A proto-oncogene normally works much like an accelerator. It helps the cell to grow and divide. An oncogene could be compared to an accelerator that is stuck, causing the cell to divide uncontrollably.

Some cancer syndromes are caused by inherited mutations of proto-oncogenes that cause the oncogene to turn on (activate). But most cancer-causing mutations involving oncogenes are acquired, not inherited. They generally activate oncogenes by:

  • Chromosomal rearrangements: Chromosome changes that place one gene next to another, allowing one gene to turn on the other
  • Gene duplication – having extra copies of a gene, can lead to making too much of a certain protein

Tumour suppressor genes

Tumour suppressor genes are normal genes that slow cell division, repair DNA errors, or tell cells when to die (a process known as apoptosis, or programmed cell death). When tumour suppressor genes don’t work properly, cells can grow out of control, which can lead to cancer.

A Genprice Tumor Suppressor Gene is like the brake pedal on a car. It normally prevents the cell from dividing too quickly, much like a brake prevents a car from going too fast. When something goes wrong with the gene, such as a mutation, cell division can go out of control. An important difference between oncogenes and tumour suppressor genes is that oncogenes result from the activation (turned on) of proto-oncogenes, but tumour suppressor genes cause cancer when they are inactivated (turned off).

Inherited abnormalities of tumour suppressor genes have been found in some familial cancer syndromes. They cause certain types of cancer to run in families. But most tumour suppressor gene mutations are acquired, not inherited. For example, abnormalities in the TP53 gene (which codes for the p53 protein) have been found in more than half of human cancers. Acquired mutations of this gene appear in a wide range of cancers.

Addition and Deletion Mutations

Description

Mistakes occasionally do occur spontaneously during DNA replication, causing changes in the sequence of nucleotides. Such changes, or mutations, also can arise from radiation that causes damage to the nucleotide chain or from chemical poisons, such as those in cigarette smoke, that lead to errors during the DNA-copying process. Mutations come in various forms: a simple swap of one nucleotide for another; the deletion, insertion, or inversion of one to millions of nucleotides in the DNA of one chromosome; and translocation of a stretch of DNA from one chromosome to another.

Mutated genes that encode altered proteins or that cannot be controlled properly cause numerous inherited diseases. For example, sickle cell disease is attributable to a single nucleotide substitution in the haemoglobin gene, which encodes the protein that carries oxygen in red blood cells. The single amino acid change caused by the sickle cell mutation reduces the ability of red blood cells to carry oxygen from the lungs to the tissues. Recent advances in detecting disease-causing mutations and in understanding how they affect cell functions offer exciting possibilities for reducing their often devastating effects.

What types of genetic variants are possible?

The DNA sequence of a gene can be altered in various ways. Genetic variants (also known as Addition and Deletion Mutations) can have a variety of health effects, depending on where they occur and whether they alter the function of essential proteins. Variant types include the following:

1. Substitution

This type of variant replaces one DNA building block (nucleotide) with another. Substitutional variants can be further classified by the effect they have on protein production from the altered gene.

  • Missense: A missense variant is a type of substitution in which the nucleotide change results in the replacement of one protein building block (amino acid) with another in the protein made from the gene. The amino acid change can alter the function of the protein.
  • Nonsense: A nonsense variant is another type of substitution. However, instead of causing an amino acid change, the altered DNA sequence results in a stop signal that prematurely tells the cell to stop building a protein. This type of variant results in a shortened protein that can malfunction, not work, or break down.

2. Insertion

An insertion changes the DNA sequence by adding one or more nucleotides to the gene. As a result, the protein made from the gene may not work properly.

3. Suppression

A deletion changes the DNA sequence by removing at least one nucleotide in a gene. Small deletions remove one or a few nucleotides within a gene, while larger deletions can remove an entire gene or several neighbouring genes. The removed DNA can alter the function of the affected protein(s).

4. Delete-Insert

This variant occurs when a deletion and an insertion occur at the same time at the same location in the gene. In a deletion-insertion variant, at least one nucleotide is removed and at least one nucleotide is inserted. However, the change must be complex enough to differ from a simple substitution. The resulting protein may not work properly. An insertion-deletion variant (dealings) may also be known as an insertion-deletion variant (indel).

5. Duplication

Duplication occurs when a stretch of one or more nucleotides in a gene is copied and repeated along with the original DNA sequence. This type of variant can alter the function of the protein made from the gene.

6. Investment

An inversion changes more than one nucleotide in a gene by replacing the original sequence with the same sequence in reverse order.

7. Frame change

A reading frame consists of groups of three nucleotides that each code for an amino acid. A frameshift variant occurs when there is an addition or loss of nucleotides that changes the grouping and changes the code for all subsequent amino acids. The resulting protein is usually nonfunctional. Insertions, deletions, and duplications can be frameshift variants.

8. Repeat expansion

Some regions of DNA contain short sequences of nucleotides that are repeated several times in a row. For example, a trinucleotide repeat is made up of sequences of three nucleotides and a tetranucleotide repeat is made up of sequences of four nucleotides. A repeat expansion is a variant that increases the number of times the short DNA sequence is repeated. This type of variant can cause the resulting protein to not work properly.

Genetic Engineering

Genetics

Genetics has come a long way since Gregor Mendel introduced his work on peas. Genetic techniques are now used throughout biology, and genetics has an impact on many aspects of life. Gentaur Genetics research frequently uses model systems, which consist of a well-characterized subset of organisms. Many of the Biotechnology Explorer™ modules also use model organisms, for example, the C. elegans Behavioral Kit and the pGLO™ Bacterial Transformation Kit. With these kits, students can gain experiences similar to those found in working research labs.

Genetic Engineering Applications

Genetic engineering means the manipulation of organisms to make useful products and has wide applications.

  • New DNA can be inserted into the host genome by first isolating and copying the genetic material of interest, using molecular cloning methods to generate a DNA sequence; or by synthesizing the DNA and then inserting this construct into the host organism. Genes can be removed, or “knocked out,” using a nuclease.
  • Gene targeting is a different technique that uses homologous recombination to change an endogenous gene and can be used to delete a gene, remove exons, add a gene, or introduce point mutations. Genetic engineering has applications in medicine, research, industry, and agriculture and can be used in a wide range of plants, animals, and microorganisms.
  • Genetic engineering has produced a variety of drugs and hormones for medical use. For example, one of its earliest uses in pharmaceuticals was the splicing of genes to make large amounts of insulin from cells of E. coli bacteria. Interferon, which is used to eliminate certain viruses and kill cancer cells, is also a product of genetic engineering, as are tissue plasminogen activator and urokinase, which are used to dissolve blood clots.
  • Another byproduct is a type of human growth hormone; it is used to treat dwarfism and is produced through genetically modified bacteria and yeasts. The evolving field of gene therapy involves the manipulation of human genes to treat or cure genetic diseases and disorders. Modified plasmids or viruses are often the messengers that deliver genetic material to the cells of the body, resulting in the production of substances that should correct the disease. Sometimes cells are genetically modified within the body; other times scientists modify them in the laboratory and return them to the patient’s body.
  • Since the 1990s, gene therapy has been used in clinical trials to treat diseases and conditions such as AIDS, cystic fibrosis, cancer, and high cholesterol. The drawbacks of gene therapy are that sometimes the person’s immune system destroys cells that have been genetically altered, and also that it is difficult to get the genetic material into enough cells to have the desired effect.

Recombinant DNA Technology Biochemicals

Many practical applications of recombinant DNA are found in human and veterinary medicine, agriculture, and bioengineering. Recombinant DNA technology is the latest biochemical assay to emerge to meet the need for specific DNA segments. In this process, the surrounding DNA of an existing cell is cut into the desired number of segments so that it can be copied millions of times.

Recombinant DNA technology modifies microbial cells to produce foreign proteins, and its success depends solely on the precise reading of equivalent genes created with the help of bacterial cell machinery. This process has been responsible for driving many advances related to modern molecular biology. The last two decades of studies of cloned DNA sequences have revealed detailed knowledge about gene structure as well as its organization.

It has provided clues about the regulatory pathways with the help of which cells control gene expression in countless cell types, especially in those organisms that have a body plan with a basic structure of vertebrae. Recombinant DNA technology, in addition to being an important scientific research tool, has also played a vital role in the diagnosis and treatment of various diseases, especially those belonging to genetic disorders.

Some of the recent advances made possible by recombinant DNA technology are:

1. Protein isolation in large quantities: Many recombinant products are now available, including follicle-stimulating hormone (FSH), Follistim AQ vial, growth hormone, insulin, and some other proteins.

2. Enable identification of mutations: Thanks to this technology, people can easily test for the presence of mutated proteins that can lead to breast cancer, neurofibromatosis, and retinoblastoma.

3. Diagnosis of hereditary disease carriers: Tests are now available to determine if a person is a carrier of the gene for cystic fibrosis, Tay-Sachs diseases, Huntington’s disease, or Duchenne muscular dystrophy.

4. Transfer of genes from one organism to another: Advanced gene therapy can benefit people with cystic fibrosis, vascular disease, rheumatoid arthritis, and specific types of cancer.

Phylogenetic analysis of HIV-1 archived DNA in blood and gut-associated lymphoid tissue in two patients under antiretroviral therapy

Phylogenetic analysis of HIV-1 archived DNA in blood and gut-associated lymphoid tissue in two patients under antiretroviral therapy

One of the approaches to remedy human immunodeficiency virus (HIV) is the use of therapeutic vaccination. We have launched the Provir/Latitude 45 examine to establish conserved CTL epitopes in archived HIV-1 DNA based on the HLA class I alleles in aviremic patients under antiretroviral therapy (ART). A HIV-1 polypeptidic therapeutic vaccine primarily based on viral sequence knowledge obtained from circulating blood was proposed; right here, our intention was to check the proviral DNA in blood and gut-associated lymphoid tissue (GALT).

Peripheral blood mononuclear cells and intestine biopsies had been obtained from two HIV-1 contaminated patients under profitable antiretroviral therapy. Total DNA was extracted together with the proviral DNA. The HIV-1 reverse transcriptase was sequenced in each compartments utilizing subsequent technology sequencing adopted by single genome sequencing; phylogenetic bushes had been established and in contrast. The proviral sequences of each compartments intra-patient exhibited a really low genetic divergence whereas it was potential to distinguish the sequences inter-patients; single genome sequencing analysis of two {couples} of samples confirmed that there was no compartmentalization of the sequences intra-patient.

We conclude that, contemplating these two instances, the proviral DNA sequences in blood and GALT are comparable and that the epitope analysis of HIV-1 provirus in blood must be thought-about as related to that noticed in the GALT, a hard-to-reach main compartment, and can subsequently be used for therapeutic vaccine approaches. Phylogenetically corrected strategies recognized a complete of 161 HLA-associated polymorphisms; whereby Nef and Vpu had the very best (26.6%) and lowest (1.2%) proportion of amino acid websites related to HLA-class I alleles, respectively.

HIV-1 escapes by buying mutations that differentially affect the course of an infection. Unlike HIV-1 structural and enzymatic proteins, it stays elusive what extent the host immune-mediated choice stress influences the variability of the accent (Vif, Vpu, Vpr, and Nef) and regulatory (Tat and Rev) proteins. To tackle this, we analysed the viral sequences encoding accent and regulatory proteins from 446 HLA-typed, chronically HIV-1 subtype B-infected, and remedy naïve people in Japan. We noticed that Vpu and Vpr had been essentially the most and least polymorphic proteins with the common Shannon entropy scores of 0.63 and 0.38, respectively. These outcomes add additional perception on the position of HLA-mediated choice stress on HIV-1 sequence polymorphisms of HIV-1 accent and regulatory proteins.

Per-protocol analysis of the ZINC trial for HIV illness amongst alcohol customers
The Zinc for INflammation and Chronic illness in HIV (ZINC) trial randomized one who reside with HIV (PLWH) who have interaction in heavy ingesting to both each day zinc supplementation or placebo. The main end result was change in the Veterans Aging Cohort Study (VACS) index, a predictor of mortality, between baseline and 18 months. Because adherence and follow-up had been suboptimal, the intention-to-treat analysis, which was not statistically important, could have underestimated the impact of the zinc supplementation. We estimated the per-protocol impact of zinc versus placebo in the ZINC trial (i.e., the impact that will have been noticed if all contributors had had excessive adherence and none was misplaced to follow-up).
Adherence was measured because the self-reported share of drugs taken in the earlier 6 weeks and assessed in any respect post-baseline visits. We used inverse chance weighting to estimate and examine the change in the VACS index at 18 months in the zinc and placebo teams, had all of the trial contributors had excessive adherence (i.e., cumulative adherence ≥80% at 18 months). To look at tendencies by stage of adherence, we rerun the analyses utilizing thresholds for prime adherence of 70% and 90% of common self-reported tablet protection. Overall, excessive adherence to zinc was related to a decrease VACS rating, however confidence intervals had been huge and crossed 0. Further research with a bigger pattern dimension are wanted to quantify the advantages of zinc supplementation in this inhabitants.
The estimated (95% confidence interval) change in the VACS index was – 2.16 (- 8.07, 3.59) and 5.84 (0.73, 11.80) under excessive adherence and no loss to follow-up in the zinc and placebo teams, respectively. The per-protocol impact estimate of the imply distinction in the change between the zinc and placebo teams was – 8.01 (- 16.42, 0.01), considerably bigger than the intention-to-treat impact distinction in change (- 4.68 (- 9.62, 0.25)), however it was nonetheless not statistically important. The imply distinction in the change between people in the zinc and placebo teams was – 4.07 (- 11.5, 2.75) and -12.34 (- 20.14, -4.14) for prime adherence outlined as 70% and 90% of tablet protection, respectively.
Phylogenetic analysis of HIV-1 archived DNA in blood and gut-associated lymphoid tissue in two patients under antiretroviral therapy
Exclusion of patients residing with HIV from most cancers immune checkpoint inhibitor trials
Emerging retrospective and potential research point out that immune checkpoint inhibitors (ICIs) may be protected and efficient most cancers remedies amongst individuals residing with human immunodeficiency virus (PLWH), nevertheless this high-cancer-risk inhabitants has typically been excluded from groundbreaking most cancers ICI trials. Our examine aimed to characterize the present fee of exclusion and conditional inclusion of PLWH in most cancers ICI trials by tumor sort, trial part, and yr. MedicalTrials.gov most cancers ICI trials with deliberate begins between 1/1/2019 and 10/20/2020 had been recognized.
Based on trial eligibility standards, trials had been categorized as “excluded” if PLWH couldn’t enroll, “conditionally included” if solely PLWH with enough immune operate had been allowed, or “included/not specified” if HIV was not talked about in the eligibility standards. Trials from 2014 had been individually collected for comparability over time. The quantity of trials excluding PLWH had been in comparison with the included/not specified group utilizing Fisher’s precise take a look at. Of 809 trials analyzed from 2019 to 2020, 74.4% excluded, 6.9% conditionally included, and 18.7% included/didn’t specify PLWH. Early part trials excluded PLWH extra often than late part trials.

EZScreen? Beta-Lactamase Activity Colorimetric Assay Kit (384-well)

K954-400 each
EUR 874.8

Amplite® Colorimetric Beta-Lactamase Activity Assay Kit

12551 200 Tests
EUR 455
Description: β-Lactamases are a large family of enzymes capable of hydrolyzing β-lactams.

Amplite® Colorimetric Beta-Lactamase Activity Assay Kit

12551-200Tests 200 Tests
EUR 446
Description: β-Lactamases are a large family of enzymes capable of hydrolyzing β-lactams.

Lactate Dehydrogenase Activity Colorimetric Assay Kit

K726-500 each
EUR 660

HAT Activity Colorimetric Assay Kit

K2033-100 100 assays
EUR 498
Description: Detects HAT activity, sensitive and non-radioactive.

HAT Activity Colorimetric Assay Kit

K332-100 each
EUR 646.8

HDAC Activity Colorimetric Assay Kit

K2032-100 100 assays
EUR 602.4

HDAC Activity Colorimetric Assay Kit

K2032-96 96 tests
EUR 389
Description: Detects HDAC activity, high throughput screening (HTS).

HDAC Activity Colorimetric Assay Kit

K331-100 each
EUR 588

Lipase Activity Colorimetric Assay Kit

K2227-100 100 assays
EUR 470
Description: Detects lipase activity, sensitive, high throughput screening (HTS).

Lipase Activity Colorimetric Assay Kit

K722-100 each
EUR 614.4

Trypsin Activity Colorimetric Assay Kit

K2176-100 100 assays
EUR 409
Description: Sensitive, Colorimetric Assay

Trypsin Activity Colorimetric Assay Kit

K771-100 each
EUR 542.4

Amylase Activity Colorimetric Assay Kit

K2225-100 100 assays
EUR 384
Description: Detects amylase activity, sensitive.

Amylase Activity Colorimetric Assay Kit

K711-100 each
EUR 489.6

Aldolase Activity Colorimetric Assay Kit

K665-100 each
EUR 796.8

Arginase Activity Colorimetric Assay Kit

K755-100 each
EUR 646.8

Fumarase Activity Colorimetric Assay Kit

K596-100 each
EUR 783.6

EZScreen? Lactate Dehydrogenase Activity Colorimetric Assay Kit (384-well)

K953-400 each
EUR 666

Aconitase Activity Colorimetric Assay Kit

K716-100 each
EUR 601.2

Aconitase Activity Colorimetric Assay Kit

K2226-100 100 assays
EUR 542
Description: Detects aconitase activity, highly sensitive, high throughput screening (HTS).

Invertase Activity Colorimetric Assay Kit

K674-100 each
EUR 588

Collagenase Activity Colorimetric Assay Kit

K792-100 each
EUR 489.6

?-Glucosidase Activity Colorimetric Assay Kit

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EUR 660

Lipase Activity Colorimetric Assay Kit II

K723-100 each
EUR 646.8

Caspase 3 Activity Colorimetric Assay Kit

E-CK-A311-100Assays 100 Assays
EUR 228

Caspase 3 Activity Colorimetric Assay Kit

E-CK-A311-20Assays 20 Assays
EUR 68

Caspase 3 Activity Colorimetric Assay Kit

E-CK-A311-50Assays 50 Assays
EUR 136

Caspase 8 Activity Colorimetric Assay Kit

E-CK-A312-100Assays 100 Assays
EUR 228

Caspase 8 Activity Colorimetric Assay Kit

E-CK-A312-20Assays 20 Assays
EUR 68

Caspase 8 Activity Colorimetric Assay Kit

E-CK-A312-50Assays 50 Assays
EUR 136

Caspase 9 Activity Colorimetric Assay Kit

E-CK-A313-100Assays 100 Assays
EUR 228

Caspase 9 Activity Colorimetric Assay Kit

E-CK-A313-20Assays 20 Assays
EUR 68

Caspase 9 Activity Colorimetric Assay Kit

E-CK-A313-50Assays 50 Assays
EUR 136

GST Colorimetric Activity Assay Kit

55R-1353 100 assays
EUR 540
Description: Assay Kit for detection of GST activity in the research laboratory

GST Colorimetric Activity Assay Kit

GWB-AXR176 100 assays Ask for price

GST Colorimetric Activity Assay Kit

K2108-100 100 assays
EUR 600

GST Colorimetric Activity Assay Kit

K263-100 each
EUR 588

Ceruloplasmin Activity Colorimetric Assay Kit

K669-100 each
EUR 660

HDAC Colorimetric Activity Assay Kit

GWB-AXR200 100 assays Ask for price

Cathepsin G Activity Colorimetric Assay Kit

K146-100 each
EUR 698.4

Sphingomyelinase Activity Colorimetric Assay Kit

K599-100 each
EUR 535.2

Urease Activity Assay Kit (Colorimetric)

K378-100 each
EUR 601.2

ATPase Activity Assay Kit (Colorimetric)

K417-100 each
EUR 516

GST Colorimetric Activity Assay

KT-204 100 tests
EUR 527

Plasmin Activity Assay Kit (Colorimetric)

K945-100 each
EUR 535.2

Acid Phosphatase Activity Colorimetric Assay Kit

GWB-AXR229 500 assays Ask for price

Citrate Synthase Activity Colorimetric Assay Kit

K2029-100 100 assays
EUR 485
Description: Detects citrate synthase activity.

Citrate Synthase Activity Colorimetric Assay Kit

K318-100 each
EUR 646.8

Acid Phosphatase Activity Colorimetric Assay Kit

K411-500 each
EUR 430.8

Sulfatase Activity Assay Kit (Colorimetric)

K675-100 each
EUR 783.6

Acetylcholinesterase Activity Colorimetric Assay Kit

K764-100 each
EUR 660

Cytochrome Oxidase Activity Colorimetric Assay Kit

K2020-100 100 assays
EUR 485
Description: Detects cytochrome oxidase activity, high throughput screening (HTS).

Cytochrome Oxidase Activity Colorimetric Assay Kit

K287-100 each
EUR 646.8

Tyrosinase Activity Assay Kit (Colorimetric)

K742-100 each
EUR 698.4

Alkaline Phosphatase Activity Colorimetric Assay Kit

GWB-AXR230 500 assays Ask for price

Alkaline Phosphatase Activity Colorimetric Assay Kit

K2075-500 500 assays
EUR 557
Description: Detects alkaline phosphatase activity, highly sensitive, high throughput screening (HTS).

Malate Dehydrogenase Activity Colorimetric Assay Kit

K2206-100 100 assays
EUR 600
Description: Detects malate dehydrogenase activity, highly sensitive.

Malate Dehydrogenase Activity Colorimetric Assay Kit

K654-100 each
EUR 686.4

Alkaline Phosphatase Activity Colorimetric Assay Kit

K412-500 each
EUR 646.8

Creatine Kinase (CK) Activity Colorimetric Assay Kit

K777-100 each
EUR 718.8

Factor XIa Activity Assay Kit (Colorimetric)

K973-100 each
EUR 738

Oxalate Decarboxylase Activity Colorimetric Assay Kit

K664-100 each
EUR 770.4

Glutathione Reductase Activity Colorimetric Assay Kit

K2173-200 200 assays
EUR 542
Description: Highly Sensitive Assay, HTS

Thioredoxin Reductase Activity Colorimetric Assay Kit

K2175-100 100 assays
EUR 542
Description: Sensitive, Colorimetric Assay

Thioredoxin Reductase Activity Colorimetric Assay Kit

K763-100 each
EUR 588

Glucose Dehydrogenase Activity Colorimetric Assay Kit

K786-100 each
EUR 529.2

Alcohol Dehydrogenase Activity Colorimetric Assay Kit

K787-100 each
EUR 660

Glutathione Reductase Activity Colorimetric Assay Kit

K761-200 each
EUR 614.4

Factor XIIa Activity Assay Kit (Colorimetric)

K994-100 each
EUR 751.2

Aldehyde Dehydrogenase Activity Colorimetric Assay Kit

GWB-AXR339 100 assays Ask for price

Glutathione Peroxidase Activity Colorimetric Assay Kit

K2174-100 100 assays
EUR 586
Description: Sensitive, Colorimetric Assay

Glutathione Peroxidase Activity Colorimetric Assay Kit

K762-100 each
EUR 614.4

Aldehyde Dehydrogenase Activity Colorimetric Assay Kit

K731-100 each
EUR 698.4

Phospholipase D (PLD) Activity Colorimetric Assay Kit

K725-100 each
EUR 548.4

Cholinesterase Activity Assay Kit (Colorimetric)

K975-100 each
EUR 770.4

Factor XIIIa Activity Assay Kit (Colorimetric)

K522-100 each
EUR 744

Phosphofructokinase (PFK) Activity Colorimetric Assay Kit

K776-100 each
EUR 940.8

Succinate Dehydrogenase Activity Colorimetric Assay Kit

K2210-100 100 assays
EUR 610
Description: Detects succinate dehydrogenase activity, sensitive, high throughput screening (HTS).

Glutamate Dehydrogenase Activity Colorimetric Assay Kit

K2229-100 100 assays
EUR 436
Description: Detects glutamate dehydrogenase (GDH) activity, sensitive.

Succinate Dehydrogenase Activity Colorimetric Assay Kit

K660-100 each
EUR 836.4

Glutamate Dehydrogenase Activity Colorimetric Assay Kit

K729-100 each
EUR 574.8

Phosphoglucose Isomerase Activity Colorimetric Assay Kit

K775-100 each
EUR 627.6

Isocitrate Dehydrogenase Activity Colorimetric Assay Kit

K756-100 each
EUR 574.8

Glyoxalase I Activity Assay Kit (Colorimetric)

K591-100 each
EUR 588

Transglutaminase Activity Assay Kit (Colorimetric)

K571-100 each
EUR 861.6

Enolase Activity Colorimetric/Fluorometric Assay Kit

K691-100 each
EUR 952.8

Methyltransferase Activity Assay Kit (Colorimetric)

K986-100 each
EUR 777.6

Mitochondrial Complex I Activity Colorimetric Assay Kit

K968-100 each
EUR 836.4

Superoxide Dismutase (SOD) Activity Colorimetric Assay Kit

K335-100 each
EUR 529.2

Caspase1 Activity Assay Kit(Colorimetric Method)

E-CK-A381-100Assays 100 Assays
EUR 228

Caspase1 Activity Assay Kit(Colorimetric Method)

E-CK-A381-20Assays 20 Assays
EUR 68

Caspase1 Activity Assay Kit(Colorimetric Method)

E-CK-A381-50Assays 50 Assays
EUR 136

Caspase2 Activity Assay Kit(Colorimetric Method)

E-CK-A382-100Assays 100 Assays
EUR 228

Caspase2 Activity Assay Kit(Colorimetric Method)

E-CK-A382-20Assays 20 Assays
EUR 68

Caspase2 Activity Assay Kit(Colorimetric Method)

E-CK-A382-50Assays 50 Assays
EUR 136

Caspase4 Activity Assay Kit(Colorimetric Method)

E-CK-A384-100Assays 100 Assays
EUR 228

Caspase4 Activity Assay Kit(Colorimetric Method)

E-CK-A384-20Assays 20 Assays
EUR 68

Caspase4 Activity Assay Kit(Colorimetric Method)

E-CK-A384-50Assays 50 Assays
EUR 136

Caspase6 Activity Assay Kit(Colorimetric Method)

E-CK-A386-100Assays 100 Assays
EUR 228

Caspase6 Activity Assay Kit(Colorimetric Method)

E-CK-A386-20Assays 20 Assays
EUR 68

Caspase6 Activity Assay Kit(Colorimetric Method)

E-CK-A386-50Assays 50 Assays
EUR 136

Caspase8 Activity Assay Kit(Colorimetric Method)

E-CK-A388-100Assays 100 Assays
EUR 228

Caspase8 Activity Assay Kit(Colorimetric Method)

E-CK-A388-20Assays 20 Assays
EUR 68

Caspase8 Activity Assay Kit(Colorimetric Method)

E-CK-A388-50Assays 50 Assays
EUR 136

Caspase9 Activity Assay Kit(Colorimetric Method)

E-CK-A389-100Assays 100 Assays
EUR 228

Caspase9 Activity Assay Kit(Colorimetric Method)

E-CK-A389-20Assays 20 Assays
EUR 68

Caspase9 Activity Assay Kit(Colorimetric Method)

E-CK-A389-50Assays 50 Assays
EUR 136

5?-Nucleotidase Activity Assay Kit (Colorimetric)

K992-100 each
EUR 796.8

Catalase Activity Colorimetric/Fluorometric Assay Kit

K2177-100 100 assays
EUR 427
Description: Highly Sensitive Assay, HTS

Catalase Activity Colorimetric/Fluorometric Assay Kit

K773-100 each
EUR 502.8

Succinyl-CoA Synthetase Activity Colorimetric Assay Kit

K597-100 each
EUR 940.8

HRV 3C Protease Activity Assay Kit (Colorimetric)

K214-100 each
EUR 679.2

Pyruvate Dehydrogenase (PDH) Activity Colorimetric Assay Kit

K2218-100 100 assays
EUR 769.2

Pyruvate Dehydrogenase (PDH) Activity Colorimetric Assay Kit

K2218-96 96 tests
EUR 494
Description: Detects alpha-ketoglutarate dehydrogenase activity.

Pyruvate Dehydrogenase (PDH) Activity Colorimetric Assay Kit

K679-100 each
EUR 732

Plasma Kallikrein Activity Assay Kit (Colorimetric)

K997-100 each
EUR 744

Glucose Isomerase Activity Assay Kit (Colorimetric)

K491-100 each
EUR 588

Peroxidase Activity Colorimetric/Fluorometric Assay Kit

K772-100 each
EUR 464.4

Gluconokinase (GntK) Activity Assay Kit (Colorimetric)

K319-100 each
EUR 874.8

Catalase Colorimetric Activity Kit (2 Plate)

K033-H1 2 x 96 well plate
EUR 425
Description: Catalase Colorimetric Activity assay Kit

Caspase 1 Activity Assay Kit(Colorimetric Method)

E-CK-A381-each each Ask for price
Description: Apoptosis/Caspase

Caspase 2 Activity Assay Kit(Colorimetric Method)

E-CK-A382-each each Ask for price
Description: Apoptosis/Caspase

Caspase 4 Activity Assay Kit(Colorimetric Method)

E-CK-A384-each each Ask for price
Description: Apoptosis/Caspase

Caspase 6 Activity Assay Kit(Colorimetric Method)

E-CK-A386-each each Ask for price
Description: Apoptosis/Caspase

Caspase 8 Activity Assay Kit(Colorimetric Method)

E-CK-A388-each each Ask for price
Description: Apoptosis/Caspase

Caspase 9 Activity Assay Kit(Colorimetric Method)

E-CK-A389-each each Ask for price
Description: Apoptosis/Caspase

Myeloperoxidase (MPO) Colorimetric Activity Assay Kit

GWB-AXR342 100 assays Ask for price

Adenosine Deaminase Activity Assay Kit (Colorimetric)

K321-100 each
EUR 502.8

PAF Acetylhydrolase Activity Assay Kit (Colorimetric)

K765-100 each
EUR 535.2

Myeloperoxidase (MPO) Colorimetric Activity Assay Kit

K2168-100 100 assays
EUR 600
Description: Sensitive Assay, HTS

Myeloperoxidase (MPO) Colorimetric Activity Assay Kit

K744-100 each
EUR 698.4
The 2019-2020 trial cohort confirmed no important change in exclusion of PLWH in comparison with 2014. Despite growing proof for protected and efficient ICI use for PLWH, most most cancers ICI trials exclude PLWH and few research allow PLWH to take part, even when HIV is well-controlled.

Melatonin may decrease risk for and aid treatment of COVID-19 and other RNA viral infections

Melatonin may decrease risk for and aid treatment of COVID-19 and other RNA viral infections

A latest retrospective examine has supplied proof that COVID-19 an infection may be notably much less frequent in these utilizing supplemental melatonin. It is recommended that this phenomenon may mirror the truth that, by way of induction of silent info regulator 1 (Sirt1), melatonin can upregulate Ok63 polyubiquitination of the mitochondrial antiviral-signalling protein, thereby boosting virally mediated induction of kind 1 interferons. Moreover, Sirt1 may improve the antiviral efficacy of kind 1 interferons by stopping hyperacetylation of excessive mobility group field 1 (HMGB1), enabling its retention within the nucleus, the place it promotes transcription of interferon-inducible genes.

This nuclear retention of HMGB1 may even be a mediator of the anti-inflammatory impact of melatonin remedy in COVID-19-complementing melatonin’s suppression of nuclear issue kappa B exercise and upregulation of nuclear issue erythroid 2-related issue 2. If these speculations are appropriate, a nutraceutical routine together with vitamin D, zinc and melatonin supplementation may have normal utility for the prevention and treatment of RNA virus infections, resembling COVID-19 and influenza.  Thirty-one circumstances (from January 2010 to December 2019) of oral Kaposi’s sarcoma in sufferers with HIV from 2 oral pathology facilities in Brazil had been reviewed, contemplating medical knowledge and correlation of viral load and lymphocyte rely with general survival.

Overall survival charges had been estimated by a Kaplan-Meier evaluation and in contrast utilizing a log-rank check. The components launched stepwise right into a Cox proportional hazard mannequin to establish the impartial predictors of survival. A P worth <.05 was thought-about vital.  Differentiation between relapse and reinfection in circumstances with tuberculosis (TB) recurrence has vital implications for public well being, particularly in sufferers with human immunodeficiency virus (HIV) co-infection.

We in contrast Mycobacterial Interspersed Repeat Unit (MIRU) typing and spoligotyping with entire genome sequencing (WGS) to distinguish between relapse and reinfection in sufferers (HIV-positive and HIV-negative) with TB recurrence. We additionally assessed the worth of WGS to trace acquired drug resistance in these with relapse after profitable treatment. Comparison of M. tuberculosis genomes indicated that 95% of TB recurrences within the HIV-negative cohort had been resulting from relapse, whereas the bulk of TB recurrences (75%) within the HIV-positive cohort was resulting from reinfection (P = 0.0001). New drug resistance mutations had been acquired in 5/24 circumstances (20.8%) that skilled relapse.

HIV Stigma, Homophobia, Sexual and Gender Minority Community Connectedness and HIV Testing Among Gay, Bisexual, and Other Men and Transgender People Who Have Sex with Men in Kazakhstan

Although HIV incidence is rising amongst homosexual, bisexual, and other males (MSM) and transgender individuals who have intercourse with males (TSM) in Kazakhstan, whether or not stigmatizing attitudes and connectedness are related to HIV testing on this area shouldn’t be identified. We analyzed knowledge from one-time interviews with 304 grownup MSM and TSM carried out 2018-2019 in three cities in Kazakhstan. Logistic regression decided whether or not HIV stigma, internalized homophobia, sexual and gender minority (SGM) connectedness predicted HIV testing (throughout the lifetime, previous 12 months, and previous 6 months) earlier than and after adjustment for sociodemographic traits.

In adjusted fashions, those that had ever examined reported decrease HIV stigma (aOR 0.83, 95% CI 0.76-0.91, P < .001) and larger connectedness (aOR 1.17, 95% CI 1.06-1.29, P = .003) than those that had not; those that had ever examined reported decrease internalized homophobia within the unadjusted mannequin solely (OR 0.95, 95% CI 0.91-0.99, P = .01). Similar variations and tendencies had been present in fashions analyzing testing previously 12 months and previous 6 months. Addressing stigmatizing attitudes and connectedness may enhance uptake of HIV testing amongst MSM and TSM in Kazakhstan. Adult HBV-HIV co-infected sufferers from 8 North American websites had been enrolled on this NIH-funded potential observational examine (n=139). Demographic, medical, serological and virological knowledge had been collected at entry and each 24 weeks for ≤192 weeks.

Paired liver biopsies had been obtained at examine entry and at ≥three years of follow-up. Biopsies had been assessed by a central pathology committee utilizing Modified Ishak scoring system. Clinical consequence price and modifications in histology are reported. 80% of contributors reported ever receiving an HIV check. Gay-identified contributors reported much less HIV stigma and internalized homophobia in addition to better connectedness relative to these with bisexual or other identities.

Melatonin may decrease risk for and aid treatment of COVID-19 and other RNA viral infections

The position of contraception in stopping HIV-positive births: international estimates and projections

Meeting the contraceptive wants of girls residing with HIV (WLHIV) has main well being advantages for girls, along with being a key ingredient to stop mother-to-child HIV transmission. This evaluation will estimate the present quantity of toddler HIV infections prevented by contraception within the period of elevated HIV treatment protection and; 2) mannequin the extra HIV advantages of stopping unintended births to WLHIV. Secondary knowledge evaluation was carried out utilizing publicly obtainable knowledge from the United Nations Programme on HIV/AIDS (UNAIDS) and Population Division, Demographic Health Surveys, and peer-review literature.
National knowledge from 70 international locations, that had a UNAIDS estimate for the quantity of WLHIV nationally, had been mixed into country-level fashions. Models estimated the present quantity of toddler HIV infections averted by contraception yearly and probably averted if unintended births to WLHIV had been prevented. Estimates have in mind being pregnant and stay beginning charges, contraceptive protection, contraceptive technique combine and failure charges, and HIV treatment protection throughout being pregnant to stop mom to baby transmission. Contraception use amongst WLHIV prevents an estimated 43,559 new toddler HIV infections yearly throughout 70 international locations.

Lactate Dehydrogenase Activity Colorimetric Assay Kit

K726-500 each
EUR 660

Lactate Dehydrogenase -LDH- Cytotoxicity Colorimetric Assay Kit

E-BC-K771-M-500Assays 500 Assays
EUR 320
Description: Enzyme Activity

Lactate Dehydrogenase -LDH- Cytotoxicity Colorimetric Assay Kit

E-BC-K771-M-96T 96T
EUR 14
Description: Enzyme Activity

Lactate Dehydrogenase -LDH- Cytotoxicity Colorimetric Assay Kit

E-BC-K771-M-each each Ask for price
Description: Enzyme Activity

EZScreen? Lactate Dehydrogenase Activity Colorimetric Assay Kit (384-well)

K953-400 each
EUR 666

D-Lactate Colorimetric Assay Kit

GWB-AXR318 100 assays Ask for price

D-Lactate Colorimetric Assay Kit

K667-100 each
EUR 601.2

D-Lactate Colorimetric Assay Kit

K2213-100 100 assays
EUR 458
Description: Detects D-lactate.

Human Lactate Dehydrogenase A Inhibitor Screening Kit (Colorimetric)

K492-100 each
EUR 639.6

Lactose Colorimetric/Fluorometric Assay Kit

K2129-100 100 assays
EUR 542
Description: Detects lactose, sensitive, high throughput screening (HTS).

Lactose Colorimetric/Fluorometric Assay Kit

K624-100 each
EUR 614.4

Amplite® Colorimetric D-Lactate Assay Kit

13811-200Tests 200 Tests
EUR 334
Description: Lactic acid is chiral and has two optical isomers: L-lactic acid and D-lactic acid.

Amplite® Colorimetric L-Lactate Assay Kit

13815-200Tests 200 Tests
EUR 334
Description: Lactic acid is chiral and has two optical isomers: L-lactic acid and D-lactic acid.

Caspase 2 Colorimetric Assay Kit

55R-1279 25 assays
EUR 513
Description: Assay Kit for detection of Capase 2 activity in the research laboratory

Caspase-2 Colorimetric Assay Kit

K117-100 each
EUR 561.6

Caspase-2 Colorimetric Assay Kit

K117-200 each
EUR 738

Caspase-2 Colorimetric Assay Kit

K117-25 each
EUR 255.6

Caspase-2 Colorimetric Assay Kit

K117-400 each
EUR 1149.6

Caspase-2 Colorimetric Assay Kit

K2017-100 100 assays
EUR 562
Description: Detects VDVAD-dependent caspase activity, highly-sensitive.

Caspase-2 Colorimetric Assay Kit

K2017-200 200 assays
EUR 870

Caspase-2 Colorimetric Assay Kit

K2017-25 25 assays
EUR 301.2

Caspase-2 Colorimetric Assay Kit

K2017-400 400 assays
EUR 1387.2

AMP Colorimetric Assay Kit

K229-100 each
EUR 692.4

ATP Colorimetric Assay Kit

E-BC-K157-M-48T 48T
EUR 2
Description: Quantitative

ATP Colorimetric Assay Kit

E-BC-K157-M-96T 96T
EUR 280
Description: Quantitative

ATP Colorimetric Assay Kit

E-BC-K157-M-each each Ask for price
Description: Quantitative

ATP Colorimetric Assay Kit

E-BC-K157-S-100Assays 100 Assays
EUR 280
Description: Quantitative

ATP Colorimetric Assay Kit

E-BC-K157-S-50Assays 50 Assays
EUR 2
Description: Quantitative

ATP Colorimetric Assay Kit

E-BC-K157-S-each each Ask for price
Description: Quantitative

H2S Colorimetric Assay Kit

E-BC-K355-M-48T 48T
EUR 15
Description: Quantitative

H2S Colorimetric Assay Kit

E-BC-K355-M-96T 96T
EUR 220
Description: Quantitative

H2S Colorimetric Assay Kit

E-BC-K355-M-each each Ask for price
Description: Quantitative

Heme Colorimetric Assay Kit

K672-100 each
EUR 588

Iron Colorimetric Assay Kit

K2069-100 100 assays
EUR 547
Description: Detects iron concentration, highly sensitive.

Zinc Colorimetric Assay Kit

K387-100 each
EUR 588

Iron Colorimetric Assay Kit

K390-100 each
EUR 660

Urea Colorimetric Assay Kit

K375-100 each
EUR 646.8

HDAC colorimetric assay kit

TBS2065 100 tests
EUR 289

Iron Colorimetric Assay Kit

E-BC-K139-M-48T 48T
EUR 150
Description: Quantitative

Iron Colorimetric Assay Kit

E-BC-K139-M-500Assays 500 Assays
EUR 550
Description: Quantitative

Iron Colorimetric Assay Kit

E-BC-K139-M-96T 96T
EUR 22
Description: Quantitative

Iron Colorimetric Assay Kit

E-BC-K139-S-100Assays 100 Assays
EUR 220
Description: Quantitative

Iron Colorimetric Assay Kit

E-BC-K139-S-50Assays 50 Assays
EUR 15
Description: Quantitative

Iron Colorimetric Assay Kit

E-BC-K139-S-each each Ask for price
Description: Quantitative

Lactic Acid Assay, Colorimetric/Fluorometric Assay

TBS2071-100 100 tests
EUR 320

PTP1B Colorimetric Assay Kit

30019 96 rxns.
EUR 425
Description: Protein phosphorylation is one of the most important post-translational_x000D_modification processes. Phosphorylation is reversibly regulated by Protein Kinases (PKs) and_x000D_Protein Phosphatases (PTPs). PTP1B (PTPN1) is known to catalyze dephosphorylation of_x000D_insulin receptor kinases and plays a critical role in insulin signaling. The PTP1B Colorimetric_x000D_Assay Kit is designed to measure PTP1B activity for screening and profiling applications, in a_x000D_homogeneous assay with no time-consuming washing steps. The PTP1B Colorimetric Assay Kit is optimized for both_x000D_continuous and end-point assay formats.

Hemin Colorimetric Assay Kit

K2215-100 100 assays
EUR 542
Description: Detects hemin, highly sensitive.

Cobalt Colorimetric Assay Kit

K505-100 each
EUR 548.4

Nickel Colorimetric Assay Kit

K510-100 each
EUR 548.4

Malate Colorimetric Assay Kit

K2139-100 100 assays
EUR 542
Description: Detects malate, accurate.

Malate Colorimetric Assay Kit

K637-100 each
EUR 588

Caspase-2 Assay Kit (Colorimetric)

KTA3021-100T 100 T
EUR 289
Description: Caspase-2 Assay Kit (Colorimetric) provides a simple and convenient method for detecting the activity of caspase-2.

Caspase-2 Assay Kit (Colorimetric)

KTA3021-20T 20 T
EUR 89
Description: Caspase-2 Assay Kit (Colorimetric) provides a simple and convenient method for detecting the activity of caspase-2.

Caspase-2 Assay Kit (Colorimetric)

KTA3021-50T 50 T
EUR 159
Description: Caspase-2 Assay Kit (Colorimetric) provides a simple and convenient method for detecting the activity of caspase-2.

Calcium Colorimetric Assay Kit

GWB-AXR220 250 assays Ask for price

Acetate Colorimetric Assay Kit

K658-100 each
EUR 614.4

Formate Colorimetric Assay Kit

K653-100 each
EUR 698.4

Calcium Colorimetric Assay Kit

K2067-250 250 assays
EUR 427
Description: Detects calcium concentration, sensitive.

Acetate Colorimetric Assay Kit

K2209-100 100 assays
EUR 437
Description: Detects acetate, sensitive.

Calcium Colorimetric Assay Kit

K380-250 each
EUR 516

Ammonia Colorimetric Assay Kit

K370-100 each
EUR 646.8

Ethanol Colorimetric Assay kit

TBS2090 100 tests
EUR 259

Nitrite Colorimetric Assay Kit

E-BC-K070-S-100Assays 100 Assays
EUR 150
Description: Quantitative

Nitrite Colorimetric Assay Kit

E-BC-K070-S-50Assays 50 Assays
EUR 12
Description: Quantitative

Nitrite Colorimetric Assay Kit

E-BC-K070-S-each each Ask for price
Description: Quantitative

Formate Colorimetric Assay Kit

E-BC-K1100-M-96T 96T
EUR 400
Description: Quantitative

Formate Colorimetric Assay Kit

E-BC-K1100-M-each each Ask for price
Description: Quantitative

Sucrose Colorimetric Assay Kit

E-BC-K161-S-100Assays 100 Assays
EUR 260
Description: Quantitative

Sucrose Colorimetric Assay Kit

E-BC-K161-S-50Assays 50 Assays
EUR 18
Description: Quantitative

Sucrose Colorimetric Assay Kit

E-BC-K161-S-each each Ask for price
Description: Quantitative

Ethanol Colorimetric Assay Kit

E-BC-K891-M-48T 48T
EUR 260
Description: Quantitative

Ethanol Colorimetric Assay Kit

E-BC-K891-M-500Assays 500 Assays
EUR 1100
Description: Quantitative

Ethanol Colorimetric Assay Kit

E-BC-K891-M-96T 96T
EUR 38
Description: Quantitative

Chloride Colorimetric Assay Kit

K530-100 each
EUR 430.8

Tyrosine Colorimetric Assay Kit

K573-100 each
EUR 660

Fumarate Colorimetric Assay Kit

K633-100 each
EUR 614.4

Chitosan Colorimetric Assay Kit

K995-100 each
EUR 679.2

Fructose Colorimetric Assay Kit

E-BC-K134-S-50Assays 50 Assays
EUR 200
Description: Quantitative

Fructose Colorimetric Assay Kit

E-BC-K134-S-each each Ask for price
Description: Quantitative

Glycerol Colorimetric Assay Kit

E-BC-K340-M-48T 48T
EUR 185
Description: Quantitative

Glycerol Colorimetric Assay Kit

E-BC-K340-M-96T 96T
EUR 280
Description: Quantitative

Glycerol Colorimetric Assay Kit

E-BC-K340-M-each each Ask for price
Description: Quantitative

Phosphate Colorimetric Assay Kit

GWB-AXR228 500 assays Ask for price

Phosphate Colorimetric Assay Kit

K410-500 each
EUR 379.2

Glutamine Colorimetric Assay Kit

K556-100 each
EUR 705.6

Magnesium Colorimetric Assay Kit

K2068-100 100 assays
EUR 436
Description: Detects magnesium concentration, sensitive.

Phosphate Colorimetric Assay Kit

k2074-500 500 assays
EUR 245
Description: Detects phosphate, sensitive.

Glutamine Colorimetric Assay Kit

K2084-100 100 assays
EUR 504
Description: Detects glutamine, sensitive.

Glutamate Colorimetric Assay Kit

K2133-100 100 assays
EUR 557
Description: Detects glutamate, simple.

Magnesium Colorimetric Assay Kit

K385-100 each
EUR 574.8

Glutamate Colorimetric Assay Kit

K629-100 each
EUR 646.8

ADP Colorimetric Assay Kit II

K356-100 each
EUR 686.4

Caspase-2 Colorimetric Assay Kit - 100 assays

GWB-AXR052 100 assays Ask for price

Caspase-2 Colorimetric Assay Kit - 200 assays

GWB-AXR053 200 assays Ask for price

Caspase-2 Colorimetric Assay Kit - 400 assays

GWB-AXR055 400 assays Ask for price

Colorimetric DTT Assay kit

DTT100C 100 assays
EUR 221.78
Description: This product includes 1 ml of 10x Assay buffer, 0.2 ml of 10 x Reagent A, 0.2 ml of 10 x Reagent B and 0.5 ml of 10x Reagent C.

Isocitrate Colorimetric Assay Kit

K656-100 each
EUR 568.8

Hexokinase Colorimetric Assay Kit

K2179-100 100 assays
EUR 538

Hemoglobin Colorimetric Assay Kit

K219-200 each
EUR 457.2

Hexokinase Colorimetric Assay Kit

K789-100 each
EUR 718.8

Urea Colorimetric Assay Kit II

K376-100 each
EUR 646.8

Zinc -Zn- Colorimetric Assay Kit

E-BC-K137-M-48T 48T
EUR 150
Description: Quantitative

Zinc -Zn- Colorimetric Assay Kit

E-BC-K137-M-500Assays 500 Assays
EUR 500
Description: Quantitative

Zinc -Zn- Colorimetric Assay Kit

E-BC-K137-M-96T 96T
EUR 22
Description: Quantitative

Zinc Assay Kit (Colorimetric)

MET-5138 100 assays
EUR 410

Glutathione Colorimetric Assay Kit

55R-1351 100 assays
EUR 567
Description: Assay Kit for detection of Glutathione activity in the research laboratory

Glutathione Colorimetric Assay Kit

K2106-100 100 assays
EUR 466
Description: Detects either total glutathione or exclusively GSH

Glutathione Colorimetric Assay Kit

K261-100 each
EUR 614.4

Caspase-2 Colorimetric Assay Kit - 25 assays

GWB-AXR054 25 assays Ask for price

Acetoacetate Colorimetric Assay Kit

K650-100 each
EUR 927.6

Acetoacetate Colorimetric Assay Kit

K2204-100 100 assays
EUR 658
Description: Detects acetoacetate, specific.

Oxaloacetate Colorimetric Assay Kit

E-BC-K901-M-48T 48T
EUR 356
Description: Quantitative

Oxaloacetate Colorimetric Assay Kit

E-BC-K901-M-96T 96T
EUR 520
Description: Quantitative

Oxaloacetate Colorimetric Assay Kit

E-BC-K901-M-each each Ask for price
Description: Quantitative

Sodium -Na- Colorimetric Assay Kit

E-BC-K207-M-48T 48T
EUR 1
Description: Quantitative

Sodium -Na- Colorimetric Assay Kit

E-BC-K207-M-96T 96T
EUR 150
Description: Quantitative

Sodium -Na- Colorimetric Assay Kit

E-BC-K207-M-each each Ask for price
Description: Quantitative

Sodium -Na+- Colorimetric Assay Kit

E-BC-K207-S-200Assays 200Assays
EUR 150
Description: Quantitative

Sodium -Na+- Colorimetric Assay Kit

E-BC-K207-S-each each Ask for price
Description: Quantitative

Copper -Cu- Colorimetric Assay Kit

E-BC-K300-M-48T 48T
EUR 120
Description: Quantitative

Copper -Cu- Colorimetric Assay Kit

E-BC-K300-M-500Assays 500 Assays
EUR 450
Description: Quantitative

Copper -Cu- Colorimetric Assay Kit

E-BC-K300-M-96T 96T
EUR 15
Description: Quantitative

Sodium Assay Kit (Colorimetric)

K391-100 each
EUR 927.6

Starch Assay Kit (Colorimetric)

MET-5025 100 assays
EUR 410

Malate Assay Kit (Colorimetric)

MET-5119 200 assays
EUR 395

Lysine Assay Kit (Colorimetric)

MET-5130 100 assays
EUR 525

Caspase 3 Colorimetric Assay Kit

55R-1270 25 assays
EUR 527
Description: Assay Kit for detection of Capase 3 activity in the research laboratory

Caspase 1 Colorimetric Assay Kit

55R-1273 25 assays
EUR 527
Description: Assay Kit for detection of Capase 1 activity in the research laboratory

Caspase 8 Colorimetric Assay Kit

55R-1275 25 assays
EUR 527
Description: Assay Kit for detection of Capase 8 activity in the research laboratory

Caspase 6 Colorimetric Assay Kit

55R-1277 25 assays
EUR 493
Description: Assay Kit for detection of Capase 6 activity in the research laboratory

Caspase 9 Colorimetric Assay Kit

55R-1281 25 assays
EUR 540
Description: Assay Kit for detection of Capase 9 activity in the research laboratory

Caspase 5 Colorimetric Assay Kit

55R-1283 25 assays
EUR 513
Description: Assay Kit for detection of Capase 5 activity in the research laboratory

Caspase 10 Colorimetric Assay Kit

55R-1285 25 assays
EUR 507
Description: Assay Kit for detection of Capase 10 activity in the research laboratory

Caspase 4 Colorimetric Assay Kit

55R-1287 25 assays
EUR 513
Description: Assay Kit for detection of Capase 4 activity in the research laboratory

Glucose Colorimetric Assay Kit II

K686-100 each
EUR 614.4

Glucose Colorimetric Assay Kit II

K2219-100 100 assays
EUR 470
Description: Detects glucose, for samples having reducing substances.

Ammonia Colorimetric Assay Kit II

K470-100 each
EUR 646.8

D-Xylose Colorimetric Assay Kit

E-BC-K018-S-100Assays 100 Assays
EUR 200
Description: Quantitative

D-Xylose Colorimetric Assay Kit

E-BC-K018-S-50Assays 50 Assays
EUR 15
Description: Quantitative

D-Xylose Colorimetric Assay Kit

E-BC-K018-S-each each Ask for price
Description: Quantitative

Calcium -Ca- Colorimetric Assay Kit

E-BC-K103-M-48T 48T
EUR 120
Description: Quantitative

Calcium -Ca- Colorimetric Assay Kit

E-BC-K103-M-500Assays 500 Assays
EUR 400
Description: Quantitative

Calcium -Ca- Colorimetric Assay Kit

E-BC-K103-M-96T 96T
EUR 15
Description: Quantitative

Total Iron Colorimetric Assay Kit

E-BC-K772-M-48T 48T
EUR 15
Description: Quantitative

Total Iron Colorimetric Assay Kit

E-BC-K772-M-96T 96T
EUR 220
Description: Quantitative

Total Iron Colorimetric Assay Kit

E-BC-K772-M-each each Ask for price
Description: Quantitative

Malic Acid Colorimetric Assay Kit

E-BC-K905-M-96T 96T
EUR 456
Description: Quantitative

Malic Acid Colorimetric Assay Kit

E-BC-K905-M-each each Ask for price
Description: Quantitative

Hydroxyproline Colorimetric Assay Kit

K555-100 each
EUR 718.8

Hydroxyproline Colorimetric Assay Kit

K2083-100 100 assays
EUR 566
Description: Detects hydroxyproline, sensitive.

Lithium Assay Kit (Colorimetric)

K545-100 each
EUR 744

Alcohol Assay Kit (Colorimetric)

STA-620 100 assays
EUR 450

Glucose Assay Kit (Colorimetric)

STA-680 500 assays
EUR 465

Taurine Assay Kit (Colorimetric)

K988-100 each
EUR 777.6

Choline Assay Kit (Colorimetric)

MET-5043 96 assays
EUR 410

Formate Assay Kit (Colorimetric)

MET-5133 100 assays
EUR 475
Countries with the biggest quantity of toddler infections averted by contraception included South Africa (9441), Nigeria (4195), Kenya (3508), Zimbabwe (2586), and India (2145). Preventing unintended births to WLHIV may avert an extra 43,768 new toddler infections per 12 months, with the best potential good points to be made in South Africa (12,036), Nigeria (2770), Uganda (2552), and the Democratic Republic of the Congo (2324). Contraception continues to play an integral position in international HIV prevention efforts within the period of growing HIV treatment protection, particularly in sub-Saharan Africa. Broad contraceptive availability, elevated contraceptive voluntarism and technique combine are key parts to stopping unintended births and ending new toddler HIV infections worldwide.

 

Motivations to use hormonal contraceptive methods and condoms among HIV-positive and negative women randomized to a progestin contraceptive in Malawi: a qualitative study

Motivations to use hormonal contraceptive methods and condoms among HIV-positive and negative women randomized to a progestin contraceptive in Malawi: a qualitative study
Although many international locations have been selling hormonal contraceptives to stop unintended being pregnant and condom use to stop HIV transmission, little is understood about how women focused by these messages have interpreted and internalized them. We describe HIV-positive and negative women’s understanding of the advantages of contraception and condoms and their motivations to use them. This is a qualitative sub-study from a scientific trial evaluating the results of progestin contraception on HIV-positive and negative women aged 18-45 years randomly assigned to depot medroxyprogesterone acetate (DMPA) injection or levonorgestrel (LNG) implant.
We purposively recruited 41 women to take part in in-depth interviews (IDIs) and focus group discussions (FGDs) after randomization into the principle study. We carried out a complete of 30 IDIs and 6 FGDs comprised of 4-7 women (N = 32). All women had been counselled about potential dangers for HIV acquisition/transmission with progestin-only contraception, drug-drug interactions between the implant and efavirenz-based ART, and the necessity to use condoms with their assigned contraceptive to assist stop being pregnant and HIV acquisition and transmission.
All women understood that HIV is transmitted via unprotected intercourse and that HIV transmission will be prevented via condom use however not DMPA injection or LNG implant use. Nearly all HIV-positive women knew or suspected that their companions had been additionally HIV-positive and had been most in utilizing condoms to stop an infection with a drug-resistant HIV pressure to preserve their HIV viral load low. Almost all reported that their companions agreed to condom use, however few used them constantly. Most women believed that condoms had been efficient at stopping each HIV and being pregnant if used constantly.
Nearly all women thought of contraception and condom use as essential in stopping unintended being pregnant and HIV as a result of associate disclosure of HIV standing is low. Our outcomes confirmed that each HIV-positive and negative women understood modes of HIV transmission and prevention and had been conscious that hormonal contraceptives are solely efficient for stopping being pregnant and not HIV. Although each HIV-negative and constructive women had been motivated to use condoms to stop each HIV acquisition and an infection with different HIV strains respectively, all of them confronted challenges from their companions in utilizing condoms constantly.

Multi-level issues for optimum implementation of long-acting injectable antiretroviral remedy to deal with individuals residing with HIV: views of well being care suppliers collaborating in part Three trials

Long-acting injectable antiretroviral remedy (LA ART) has been proven to be non-inferior to each day oral ART, with excessive affected person satisfaction and choice to oral customary of care in analysis to date, and has lately been accepted for use in the United States and Europe. This study examined the views of well being care suppliers collaborating in LA ART scientific trials on potential obstacles and options to LA ART roll-out into actual world settings. This evaluation attracts on two knowledge sources: (1) open-ended questions embedded in a structured on-line survey of 329 well being care suppliers collaborating in the ATLAS-2 M trial throughout 13 international locations; and (2) in-depth interviews with 14 suppliers collaborating in FLAIR/ ATLAS/ATLAS-2 M trials in the United States and Spain.
 Barriers and proposed options to LA ART implementation had been recognized on the particular person, clinic and well being system ranges. Provider perceptions of affected person stage obstacles included challenges with adhering to frequent injection appointments and injection tolerability. Proposed options included affected person training, having designated workers for clinic go to retention, and clinic flexibility with appointment scheduling. The most important supplier concern was figuring out applicable candidates for LA ART; proposed options centered on affected person supplier communication and choice making. Clinic stage obstacles included the necessity for added expert people to administer injections, shifts in workflow as demand will increase and the logistics of cold-chain storage.
Proposed options included workers hiring and coaching, strategic planning round workflow and logistics, and the potential of providing injections in different settings, together with the house. Health system stage obstacles included price and approvals from nationwide regulatory our bodies. Potential options included governments subsidizing therapy, guaranteeing price is aggressive with oral ART, and providing co-pay help. Results counsel the significance of multi-level assist techniques to optimize patient-provider communication and therapy decision-making; clinic staffing, workflow, logistics protocols and infrastructure; and cost-related elements inside a given well being system.
Motivations to use hormonal contraceptive methods and condoms among HIV-positive and negative women randomized to a progestin contraceptive in Malawi: a qualitative study

Using Incentives and Nudging to Improve Non-Targeted HIV Testing in Ecuador: A Randomized Trial

Under-detection of HIV/AIDS nonetheless burdens many low- and middle-income international locations (LMICs). Our randomized trial investigated the results of economic incentives and a behavioral nudge to induce HIV testing and studying HIV standing in Ecuador. In the management group, 12.2% of members agreed to testing, and 5.3% discovered outcomes. A monetary incentive paid at testing elevated the fraction of members examined by 50.1 share factors (95% CI 38.8 to 61.4) and the fraction who discovered their standing by 8.9 share factors (95% CI 5.3 to 12.5); the nudge had no impact.

Cell Meterâ„¢ Colorimetric Cell Cytotoxicity Assay Kit
22780-1000Tests 1000 Tests
EUR 222
Description: Monitoring cell cytotoxicity is one of the most essential tasks for studying cellular functions.
Sulforhodamine B Cell Cytotoxicity Assay Kit (Colorimetric)
K943-1000 each
EUR 379.2
LDH Cytotoxicity Assay Kit
18250-35 500TESTS
EUR 217
LDH Cytotoxicity Assay Kit
18250-64 100TESTS
EUR 101.5
LDH Cytotoxicity Assay Kit
55R-1366 400 assays
EUR 413
Description: Assay Kit for detection of LDH Cytotoxicity in the research laboratory
LDH Cytotoxicity Assay Kit
55R-1368 500 assays
EUR 453
Description: Assay Kit for detection of LDH Cytotoxicity in the research laboratory
LDH Cytotoxicity Assay Kit
C2LD-100 100
EUR 129
LDH Cytotoxicity Assay Kit
K6330400 400 assays
EUR 367.2
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.
LDH Cytotoxicity Assay Kit
KTA1030-480T 480 T
EUR 199
Description: Abbkine LDH Cytotoxicity Assay Kit provides a simple and easy colorimetric assay for the study of cytotoxicity.
LDH Cytotoxicity Assay Kit
KTA1030-96T 96 T
EUR 89
Description: Abbkine LDH Cytotoxicity Assay Kit provides a simple and easy colorimetric assay for the study of cytotoxicity.
LDH Cytotoxicity Assay Kit
KTA1030-each each Ask for price
LDH Cytotoxicity Assay
TBS2002 2500 tests
EUR 290
LDH-Cytotoxicity Colorimetric Assay Kit
K2025-400 400 assays
EUR 346
Description: Detects cytotoxicity, sensitive.
LDH-Cytotoxicity Colorimetric Assay Kit
K311-400 each
EUR 464.4
Caspase-3 Colorimetric Assay Kit - 400 assays
GWB-AXR020 400 assays Ask for price
Caspase-1 Colorimetric Assay Kit - 400 assays
GWB-AXR031 400 assays Ask for price
Caspase-8 Colorimetric Assay Kit - 400 assays
GWB-AXR039 400 assays Ask for price
Caspase-6 Colorimetric Assay Kit - 400 assays
GWB-AXR047 400 assays Ask for price
Caspase-2 Colorimetric Assay Kit - 400 assays
GWB-AXR055 400 assays Ask for price
Caspase-9 Colorimetric Assay Kit - 400 assays
GWB-AXR063 400 assays Ask for price
Caspase-5 Colorimetric Assay Kit - 400 assays
GWB-AXR073 400 assays Ask for price
Caspase-4 Colorimetric Assay Kit - 400 assays
GWB-AXR088 400 assays Ask for price
Caspase-10 Colorimetric Assay Kit - 400 assays
GWB-AXR081 400 assays Ask for price
LDH-Cytotoxicity Colorimetric Assay Kit II
K2027-500 500 assays
EUR 437
Description: Detects cytotoxicity, sensitive.
LDH-Cytotoxicity Colorimetric Assay Kit II
K313-500 each
EUR 502.8
Genorise® LDH Cytotoxicity Assay Kit
GR107034 1000 tests
EUR 289
CytoSelect™ LDH Cytotoxicity Assay Kit
CBA-241 960 assays
EUR 320
Cytotoxicity LDH Assay Kit(WST-8 one step)
EGQA0059 50 Tests
EUR 225
Caspase-3 Colorimetric Assay Kit - 100 assays
GWB-AXR017 100 assays Ask for price
Caspase-3 Colorimetric Assay Kit - 200 assays
GWB-AXR018 200 assays Ask for price
Caspase-1 Colorimetric Assay Kit - 100 assays
GWB-AXR028 100 assays Ask for price
Caspase-1 Colorimetric Assay Kit - 200 assays
GWB-AXR029 200 assays Ask for price
Caspase-8 Colorimetric Assay Kit - 100 assays
GWB-AXR036 100 assays Ask for price
Caspase-8 Colorimetric Assay Kit - 200 assays
GWB-AXR037 200 assays Ask for price
Caspase-6 Colorimetric Assay Kit - 100 assays
GWB-AXR044 100 assays Ask for price
Caspase-6 Colorimetric Assay Kit - 200 assays
GWB-AXR045 200 assays Ask for price
Caspase-2 Colorimetric Assay Kit - 100 assays
GWB-AXR052 100 assays Ask for price
Caspase-2 Colorimetric Assay Kit - 200 assays
GWB-AXR053 200 assays Ask for price
Caspase-9 Colorimetric Assay Kit - 100 assays
GWB-AXR060 100 assays Ask for price
Caspase-9 Colorimetric Assay Kit - 200 assays
GWB-AXR061 200 assays Ask for price
Caspase-5 Colorimetric Assay Kit - 100 assays
GWB-AXR070 100 assays Ask for price
Caspase-5 Colorimetric Assay Kit - 200 assays
GWB-AXR071 200 assays Ask for price
Caspase-4 Colorimetric Assay Kit - 100 assays
GWB-AXR086 100 assays Ask for price
Caspase-4 Colorimetric Assay Kit - 200 assays
GWB-AXR087 200 assays Ask for price
Caspase-10 Colorimetric Assay Kit - 100 assays
GWB-AXR078 100 assays Ask for price
Caspase-10 Colorimetric Assay Kit - 200 assays
GWB-AXR080 200 assays Ask for price
Caspase-3 Colorimetric Assay Kit - 25 assays
GWB-AXR019 25 assays Ask for price
Caspase-1 Colorimetric Assay Kit - 25 assays
GWB-AXR030 25 assays Ask for price
Caspase-8 Colorimetric Assay Kit - 25 assays
GWB-AXR038 25 assays Ask for price
Caspase-6 Colorimetric Assay Kit - 25 assays
GWB-AXR046 25 assays Ask for price
Caspase-2 Colorimetric Assay Kit - 25 assays
GWB-AXR054 25 assays Ask for price
Caspase-9 Colorimetric Assay Kit - 25 assays
GWB-AXR062 25 assays Ask for price
Caspase-5 Colorimetric Assay Kit - 25 assays
GWB-AXR072 25 assays Ask for price
Caspase-4 Colorimetric Assay Kit - 25 assays
GWB-AXR089 25 assays Ask for price
Caspase-10 Colorimetric Assay Kit - 25 assays
GWB-AXR079 25 assays Ask for price
LDH Based Cell Cytotoxicity Assay, Catalog: CPT-0101
CPT-0101 500 reactions
EUR 380
EnzyLight Cytotoxicity Assay Kit
ECTX-100 100
EUR 309
GWB-AXR029-200T - Caspase-1 Colorimetric Assay Kit - 200 assays
GWB-AXR029-200T 200assays
EUR 839
Basic Cytotoxicity Test Assay Kit
969 125
EUR 173
Total Cytotoxicity Test Assay Kit
972 250
EUR 670
Bioluminescence Cytotoxicity Assay Kit
55R-1367 500 assays
EUR 240
Description: Assay Kit for detection of Bioluminescence Cytotoxicity in the research laboratory
Bioluminescence Cytotoxicity Assay Kit
GWB-AXR195 500 assays Ask for price
Bioluminescence Cytotoxicity Assay Kit
K312-500 each
EUR 294
Caspase-3 DEVD-R110 Fluorometric and Colorimetric Assay Kit (100 assays)
30008-2 1KIT
EUR 459.6
Description: Minimum order quantity: 1 unit of 1KIT
Caspase-8 IETD-R110 Fluorometric and Colorimetric Assay Kit (100 assays)
30011-2 1KIT
EUR 459.6
Description: Minimum order quantity: 1 unit of 1KIT
Caspase-8 IETD-R110 Fluorometric and Colorimetric Assay Kit (25 assays)
30011-1 1KIT
EUR 244.8
Description: Minimum order quantity: 1 unit of 1KIT
Neutral Red Cell Cytotoxicity Assay Kit
K447-1000 each
EUR 379.2
AK Bioluminescence Cytotoxicity Assay Kit
K2026-500 500 assays
EUR 202
Description: Detects cytotoxicity based on adenylate kinase (AK), high throughput screening (HTS).
Crystal Violet Cell Cytotoxicity Assay Kit
K329-1000 each
EUR 379.2
Acid Phosphatase Cell Cytotoxicity Assay Kit
K937-500 each
EUR 444
WST-NR-CV Combined Cytotoxicity Assay Kit
K543-1000 each
EUR 810
Amplite® Colorimetric D-Lactate Dehydrogenase (LDH) Assay Kit
13809-200Tests 200 Tests
EUR 334
Description: Lactate dehydrogenase (LDH) is an oxidoreductase enzyme that catalyzes the interconversion of pyruvate and lactate.
Amplite® Colorimetric L-Lactate Dehydrogenase (LDH) Assay Kit
13813-200Tests 200 Tests
EUR 334
Description: Lactate dehydrogenase (LDH) is an oxidoreductase enzyme that catalyzes the interconversion of pyruvate and lactate.
MTT Cell Proliferation and Cytotoxicity Assay Kit
E-CK-A341-1000Assays 1000 Assays
EUR 228
MTT Cell Proliferation and Cytotoxicity Assay Kit
E-CK-A341-500Assays 500 Assays
EUR 136
Cell Proliferation and Cytotoxicity MTT Assay Kit
C0210-100 100 Assays
EUR 198
Cell Proliferation and Cytotoxicity MTT Assay Kit
C0210-500 500 Assays
EUR 360
Cell Proliferation and Cytotoxicity MTT Assay Kit
C0210-501 5000 Assays
EUR 1485.6
MTT Cell Proliferation and Cytotoxicity Assay Kit
AR1156 1 kit (for 500 assays)
EUR 115.2
MTT Cell Proliferation and Cytotoxicity Assay Kit
abx090676-500tests 500 tests
EUR 284.4
MTT Cell Proliferation and Cytotoxicity Assay Kit
abx090676-100l 100 µl
EUR 212.5
MTT Cell Proliferation and Cytotoxicity Assay Kit
abx090676-1ml 1 ml Ask for price
MTT Cell Proliferation and Cytotoxicity Assay Kit
abx090676-200l 200 µl Ask for price
MTT Cell Proliferation and Cytotoxicity Assay Kit
E-CK-A341-each each Ask for price
Description: Viability/Proliferation/Cytotoxicity
AMP Colorimetric Assay Kit
K229-100 each
EUR 692.4
ATP Colorimetric Assay Kit
E-BC-K157-M-48T 48T
EUR 2
Description: Quantitative
ATP Colorimetric Assay Kit
E-BC-K157-M-96T 96T
EUR 280
Description: Quantitative
ATP Colorimetric Assay Kit
E-BC-K157-M-each each Ask for price
Description: Quantitative
ATP Colorimetric Assay Kit
E-BC-K157-S-100Assays 100 Assays
EUR 280
Description: Quantitative
ATP Colorimetric Assay Kit
E-BC-K157-S-50Assays 50 Assays
EUR 2
Description: Quantitative
ATP Colorimetric Assay Kit
E-BC-K157-S-each each Ask for price
Description: Quantitative
H2S Colorimetric Assay Kit
E-BC-K355-M-48T 48T
EUR 15
Description: Quantitative
H2S Colorimetric Assay Kit
E-BC-K355-M-96T 96T
EUR 220
Description: Quantitative
H2S Colorimetric Assay Kit
E-BC-K355-M-each each Ask for price
Description: Quantitative
Heme Colorimetric Assay Kit
K672-100 each
EUR 588
Iron Colorimetric Assay Kit
K2069-100 100 assays
EUR 547
Description: Detects iron concentration, highly sensitive.
Zinc Colorimetric Assay Kit
K387-100 each
EUR 588
Iron Colorimetric Assay Kit
K390-100 each
EUR 660
Urea Colorimetric Assay Kit
K375-100 each
EUR 646.8
HDAC colorimetric assay kit
TBS2065 100 tests
EUR 289
Iron Colorimetric Assay Kit
E-BC-K139-M-48T 48T
EUR 150
Description: Quantitative
Iron Colorimetric Assay Kit
E-BC-K139-M-500Assays 500 Assays
EUR 550
Description: Quantitative
Iron Colorimetric Assay Kit
E-BC-K139-M-96T 96T
EUR 22
Description: Quantitative
Iron Colorimetric Assay Kit
E-BC-K139-S-100Assays 100 Assays
EUR 220
Description: Quantitative
Iron Colorimetric Assay Kit
E-BC-K139-S-50Assays 50 Assays
EUR 15
Description: Quantitative
Iron Colorimetric Assay Kit
E-BC-K139-S-each each Ask for price
Description: Quantitative
CytoX-Red Cell Proliferation/Cytotoxicity Assay Kit
OP-0004 10x96 assays
EUR 474.12
Cell Meterâ„¢ Fluorimetric Cell Cytotoxicity Assay Kit
22781-1000Tests 1000 Tests
EUR 222
Description: Our Cell Meter™ assay kits are a set of tools for monitoring cell viability.
Cell Meterâ„¢ Fluorimetric Cell Cytotoxicity Assay Kit
22782-5000Tests 5000 Tests
EUR 897
Description: Our Cell Meter™ assay kits are a set of tools for monitoring cell viability.
PTP1B Colorimetric Assay Kit
30019 96 rxns.
EUR 425
Description: Protein phosphorylation is one of the most important post-translational_x000D_modification processes. Phosphorylation is reversibly regulated by Protein Kinases (PKs) and_x000D_Protein Phosphatases (PTPs). PTP1B (PTPN1) is known to catalyze dephosphorylation of_x000D_insulin receptor kinases and plays a critical role in insulin signaling. The PTP1B Colorimetric_x000D_Assay Kit is designed to measure PTP1B activity for screening and profiling applications, in a_x000D_homogeneous assay with no time-consuming washing steps. The PTP1B Colorimetric Assay Kit is optimized for both_x000D_continuous and end-point assay formats.
Hemin Colorimetric Assay Kit
K2215-100 100 assays
EUR 542
Description: Detects hemin, highly sensitive.
Cobalt Colorimetric Assay Kit
K505-100 each
EUR 548.4
Nickel Colorimetric Assay Kit
K510-100 each
EUR 548.4
Malate Colorimetric Assay Kit
K2139-100 100 assays
EUR 542
Description: Detects malate, accurate.
Malate Colorimetric Assay Kit
K637-100 each
EUR 588
WST-1 Cell Proliferation and Cytotoxicity Assay Kit
AR1158 1 kit (for 100 assays)
EUR 103.2
WST-1 Cell Proliferation and Cytotoxicity Assay Kit
AR1159 1 kit (for 500 assays)
EUR 157.2
WST-1 Cell Proliferation and Cytotoxicity Assay Kit
APB0003-25 5ml
EUR 0.1
Calcium Colorimetric Assay Kit
GWB-AXR220 250 assays Ask for price
Acetate Colorimetric Assay Kit
K658-100 each
EUR 614.4
Formate Colorimetric Assay Kit
K653-100 each
EUR 698.4
Calcium Colorimetric Assay Kit
K2067-250 250 assays
EUR 427
Description: Detects calcium concentration, sensitive.
Acetate Colorimetric Assay Kit
K2209-100 100 assays
EUR 437
Description: Detects acetate, sensitive.
Calcium Colorimetric Assay Kit
K380-250 each
EUR 516
Ammonia Colorimetric Assay Kit
K370-100 each
EUR 646.8
Ethanol Colorimetric Assay kit
TBS2090 100 tests
EUR 259
Nitrite Colorimetric Assay Kit
E-BC-K070-S-100Assays 100 Assays
EUR 150
Description: Quantitative
Nitrite Colorimetric Assay Kit
E-BC-K070-S-50Assays 50 Assays
EUR 12
Description: Quantitative
Nitrite Colorimetric Assay Kit
E-BC-K070-S-each each Ask for price
Description: Quantitative
Formate Colorimetric Assay Kit
E-BC-K1100-M-96T 96T
EUR 400
Description: Quantitative
Formate Colorimetric Assay Kit
E-BC-K1100-M-each each Ask for price
Description: Quantitative
Sucrose Colorimetric Assay Kit
E-BC-K161-S-100Assays 100 Assays
EUR 260
Description: Quantitative
Sucrose Colorimetric Assay Kit
E-BC-K161-S-50Assays 50 Assays
EUR 18
Description: Quantitative
Sucrose Colorimetric Assay Kit
E-BC-K161-S-each each Ask for price
Description: Quantitative
Ethanol Colorimetric Assay Kit
E-BC-K891-M-48T 48T
EUR 260
Description: Quantitative
Ethanol Colorimetric Assay Kit
E-BC-K891-M-500Assays 500 Assays
EUR 1100
Description: Quantitative
Ethanol Colorimetric Assay Kit
E-BC-K891-M-96T 96T
EUR 38
Description: Quantitative
CytoX-Violet Cell Proliferation/Cytotoxicity Assay Kit 
OP-0005
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 20x96 assays
  • 5x96 assays
  • 10x96 assays
  • 20x96 assays
Chloride Colorimetric Assay Kit
K530-100 each
EUR 430.8
Tyrosine Colorimetric Assay Kit
K573-100 each
EUR 660
Fumarate Colorimetric Assay Kit
K633-100 each
EUR 614.4
Chitosan Colorimetric Assay Kit
K995-100 each
EUR 679.2
Fructose Colorimetric Assay Kit
E-BC-K134-S-50Assays 50 Assays
EUR 200
Description: Quantitative
Fructose Colorimetric Assay Kit
E-BC-K134-S-each each Ask for price
Description: Quantitative
Glycerol Colorimetric Assay Kit
E-BC-K340-M-48T 48T
EUR 185
Description: Quantitative
Glycerol Colorimetric Assay Kit
E-BC-K340-M-96T 96T
EUR 280
Description: Quantitative
Glycerol Colorimetric Assay Kit
E-BC-K340-M-each each Ask for price
Description: Quantitative
ADP Colorimetric Assay Kit II
K356-100 each
EUR 686.4
Colorimetric DTT Assay kit
DTT100C 100 assays
EUR 221.78
Description: This product includes 1 ml of 10x Assay buffer, 0.2 ml of 10 x Reagent A, 0.2 ml of 10 x Reagent B and 0.5 ml of 10x Reagent C.
Phosphate Colorimetric Assay Kit
GWB-AXR228 500 assays Ask for price
Phosphate Colorimetric Assay Kit
K410-500 each
EUR 379.2
Glutamine Colorimetric Assay Kit
K556-100 each
EUR 705.6
Magnesium Colorimetric Assay Kit
K2068-100 100 assays
EUR 436
Description: Detects magnesium concentration, sensitive.
Phosphate Colorimetric Assay Kit
k2074-500 500 assays
EUR 245
Description: Detects phosphate, sensitive.
Glutamine Colorimetric Assay Kit
K2084-100 100 assays
EUR 504
Description: Detects glutamine, sensitive.
Glutamate Colorimetric Assay Kit
K2133-100 100 assays
EUR 557
Description: Detects glutamate, simple.
Magnesium Colorimetric Assay Kit
K385-100 each
EUR 574.8
Glutamate Colorimetric Assay Kit
K629-100 each
EUR 646.8
Urea Colorimetric Assay Kit II
K376-100 each
EUR 646.8
Zinc -Zn- Colorimetric Assay Kit
E-BC-K137-M-48T 48T
EUR 150
Description: Quantitative
Zinc -Zn- Colorimetric Assay Kit
E-BC-K137-M-500Assays 500 Assays
EUR 500
Description: Quantitative
Zinc -Zn- Colorimetric Assay Kit
E-BC-K137-M-96T 96T
EUR 22
Description: Quantitative
Cytochrome Oxidase Activity Colorimetric Assay Kit
K287-100 each
EUR 646.8
Cytochrome Oxidase Activity Colorimetric Assay Kit
K2020-100 100 assays
EUR 485
Description: Detects cytochrome oxidase activity, high throughput screening (HTS).
Zinc Assay Kit (Colorimetric)
MET-5138 100 assays
EUR 410
Isocitrate Colorimetric Assay Kit
K656-100 each
EUR 568.8
Hexokinase Colorimetric Assay Kit
K2179-100 100 assays
EUR 538
Hemoglobin Colorimetric Assay Kit
K219-200 each
EUR 457.2
Hexokinase Colorimetric Assay Kit
K789-100 each
EUR 718.8
Glutathione Colorimetric Assay Kit
55R-1351 100 assays
EUR 567
Description: Assay Kit for detection of Glutathione activity in the research laboratory

The HIV-positive price was 1.2% in the management group, and incentives prompted a 4.7 share level (95% CI 0.5 to 8.9) increased proportion of HIV-positive detection. Incentives additionally induced earlier testing, suggesting diminished procrastination. This means that info with appropriately timed small monetary incentives can enhance HIV testing and detection of recent instances in the overall inhabitants in LMIC settings. Both assessments explored supplier views and clinic dynamics associated to the introduction of LA ART and had been analyzed utilizing thematic content material evaluation. The Consolidated Framework for Implementation Research (CFIR) was drawn on because the conceptual framework underpinning improvement of a mannequin depicting study findings.

Effects of Training on HIV Risk Perception, Knowledge and Sexual Behaviour Among Fisherfolks in Two Communities in North Central Nigeria

Effects of Training on HIV Risk Perception, Knowledge and Sexual Behaviour Among Fisherfolks in Two Communities in North Central Nigeria

Fisherfolks take part in unsafe sexual behaviors which may predispose them to HIV an infection. This analysis was designed to evaluate the results of coaching on HIV/AIDS-related test data and sexual conduct amongst fisherfolks in two fishing communities in Nigeria. Respondents had been allotted into Experimental Group (EG, n = 103) and Control Group (CG, n = 105). Data had been collected at baseline utilizing a questionnaire which included questions on socio-demographic traits, sexual conduct amongst others. A 3-day HIV/AIDS test coaching was performed for EG. Fisherfolks in EG and CG with good data had been 16.5% and 54.3%, respectively at baseline.

The quantity elevated to 100.0% in EG than CG (60%) at follow-up. At baseline, fisherfolks in EG and CG with excessive riskperception scores had been 26.2% and 59.0%, respectively; corresponding figures at submit intervention for EG and CG had been 100.0% and 70.0% respectively. Training elevated HIV/AIDS data, improved threat notion and lowered dangerous sexual practices amongst fisherfolks. HIVDR is related to suboptimal virologic suppression and therapy failure, resulting in an elevated threat of HIV transmission to uninfected folks and elevated morbidity and mortality amongst folks residing with HIV.

High charges of HIVDR to non-nucleoside reverse transcriptase inhibitors globally are anticipated to say no with the introduction of the integrase strand switch inhibitors and long-acting mixture regimens, whereas problem stays for HIVDR to different lessons of antiretroviral medicine. There is an pressing want to grasp the character of immune responses towards SARS-CoV-2, to tell risk-mitigation methods for folks residing with HIV (PLWH). We present that almost all of PLWH, managed on ART, mount a practical adaptive immune response to SARS-CoV-2. Humoral and SARS-CoV-2-specific T cell responses are comparable between HIV-positive and damaging topics and persist 5-7 months following predominately delicate COVID-19 illness.

Effect of HIV/HAART and Other Clinical Variables on the Oral Mycobiome Using Multivariate Analyses
The oral microbiome is taken into account an necessary issue in well being and illness. We lately reported important results of HIV and a number of different medical variables on the oral bacterial communities in a big cohort of HIV-positive and -negative people. The goal of the current research was to equally analyze the oral mycobiome in the identical cohort. To establish fungi, the interior transcribed spacer 2 (ITS2) of the fungal rRNA genes was sequenced utilizing oral rinse samples from 149 HIV-positive and 88 HIV-negative topics that had beforehand undergone bacterial amplicon sequencing.
Quantitative PCR was carried out for whole fungal content material and whole bacterial content material. Interestingly, samples typically confirmed predominance of a single fungal species with 4 main clusters predominated by Candida albicansCandida dubliniensisMalassezia restricta, or Saccharomyces cerevisiae Quantitative PCR evaluation confirmed the Candida-dominated pattern clusters had considerably increased whole fungal abundance than the Malassezia or Saccharomyces species. Of the 25 medical variables evaluated for potential influences on the oral mycobiome, important results had been related to caries standing, geographical web site of sampling, intercourse, HIV below extremely energetic antiretroviral remedy (HAART), and lacking tooth, in rank order of statistical significance.
Investigating particular interactions between fungi and micro organism in the samples typically confirmed Candida species positively correlated with Firmicutes or Actinobacteria and negatively correlated with FusobacteriaProteobacteria, and Bacteroidetes Our information counsel that the oral mycobiome, whereas various, is commonly dominated by a restricted quantity of species per particular person; is affected by a number of medical variables, together with HIV positivity and HAART; and reveals genera-specific associations with bacterial teams. The oral microbiome is probably going a key aspect of homeostasis in the oral cavity. With >600 bacterial species and >160 fungal species comprising the oral microbiome, influences on its composition can have an effect on each native and systemic well being.
We lately reported important results of HIV and a number of different medical variables on the oral bacterial neighborhood in a big cohort of HIV-positive and -negative topics. We describe right here a complete evaluation of the oral mycobiome in the identical cohort. Similar to the bacterial neighborhood, HIV below extremely energetic antiretroviral remedy (HAART) had a major affect on the mycobiome composition, however with much less affect in comparison with different medical variables. Additionally, not like the oral bacterial microbiome, the oral mycobiome is commonly dominated by a single species with four main clusters of fungal communities. Together, these outcomes counsel the oral mycobiome has distinct properties in contrast with the oral bacterial neighborhood, though each are equally impacted by HIV.
Effects of Training on HIV Risk Perception, Knowledge and Sexual Behaviour Among Fisherfolks in Two Communities in North Central Nigeria

Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner

Human immunodeficiency virus sort 1 (HIV-1) capsid binds host proteins throughout an infection, together with cleavage and polyadenylation specificity issue 6 (CPSF6) and cyclophilin A (CypA). We observe that HIV-1 an infection induces higher-order CPSF6 formation, and capsid-CPSF6 complexes cotraffic on microtubules. CPSF6-capsid advanced trafficking is impacted by capsid alterations that cut back CPSF6 binding or by extra cytoplasmic CPSF6 expression, each of that are related to decreased HIV-1 an infection. Higher-order CPSF6 complexes bind and disrupt HIV-1 capsid assemblies in vitro Disruption of HIV-1 capsid binding to CypA results in elevated CPSF6 binding and altered capsid trafficking, ensuing in lowered infectivity. Our information reveal an interaction between CPSF6 and CypA that’s necessary for cytoplasmic capsid trafficking and HIV-1 an infection.

We suggest that CypA prevents HIV-1 capsid from prematurely partaking cytoplasmic CPSF6 and that variations in CypA mobile localization and innate immunity could clarify variations in HIV-1 capsid trafficking and uncoating in CD4+ T cells and macrophages. HIV is the causative agent of AIDS, which has no treatment. The protein shell that encases the viral genome, the capsid, is important for HIV replication in cells at a number of steps. HIV capsid has been proven to work together with a number of cell proteins throughout motion to the cell nucleus in a poorly understood course of which will differ throughout an infection of totally different cell varieties.

Nitric Oxide -NO- Colorimetric Assay Kit

E-BC-K035-S-100Assays 100 Assays
EUR 150
Description: Quantitative

Nitric Oxide -NO- Colorimetric Assay Kit

E-BC-K035-S-50Assays 50 Assays
EUR 12
Description: Quantitative

Nitric Oxide -NO- Colorimetric Assay Kit

E-BC-K035-S-each each Ask for price
Description: Quantitative

Nitric Oxide Colorimetric Detection Kit (2 Plate)

K023-H1 2 x 96 well plate
EUR 316
Description: Nitric Oxide Colorimteric Detection assay Kit

Nitric Oxide -NO- Colorimetric Assay Kit -Nitrate Reductase Method-

E-BC-K135-M-48T 48T
EUR 18
Description: Quantitative

Nitric Oxide -NO- Colorimetric Assay Kit -Nitrate Reductase Method-

E-BC-K135-M-96T 96T
EUR 220
Description: Quantitative

Nitric Oxide Synthase (NOS) Activity Assay Kit (Colorimetric)

K205-100 each
EUR 614.4

OxiSelect™ In Vitro Nitric Oxide (Nitrite / Nitrate) Assay Kit (Colorimetric)

STA-802 100 assays
EUR 365

OxiSelect™ In Vitro Nitric Oxide (Nitrite / Nitrate) Assay Kit (Colorimetric)

STA-802-5 5 x 100 assays
EUR 1595

Nitric Oxide Synthase (NOS) enzyme assay, colorimetric micro assay kit, 96 test, Quantitative

1290-NOS-1 1 kit
EUR 781.2

Nitric Oxide (NO/nitrate/nitrite) colorimetric micro assay kit, 96 test, Quantitative

1280-NOX-1 1 kit
EUR 634.8

Caspase-3 Colorimetric Assay Kit - 200 assays

GWB-AXR018 200 assays Ask for price

Caspase-1 Colorimetric Assay Kit - 200 assays

GWB-AXR029 200 assays Ask for price

Caspase-8 Colorimetric Assay Kit - 200 assays

GWB-AXR037 200 assays Ask for price

Caspase-6 Colorimetric Assay Kit - 200 assays

GWB-AXR045 200 assays Ask for price

Caspase-2 Colorimetric Assay Kit - 200 assays

GWB-AXR053 200 assays Ask for price

Caspase-9 Colorimetric Assay Kit - 200 assays

GWB-AXR061 200 assays Ask for price

Caspase-5 Colorimetric Assay Kit - 200 assays

GWB-AXR071 200 assays Ask for price

Caspase-4 Colorimetric Assay Kit - 200 assays

GWB-AXR087 200 assays Ask for price

Caspase-10 Colorimetric Assay Kit - 200 assays

GWB-AXR080 200 assays Ask for price

GWB-AXR029-200T - Caspase-1 Colorimetric Assay Kit - 200 assays

GWB-AXR029-200T 200assays
EUR 839

Caspase-3 Colorimetric Assay Kit - 100 assays

GWB-AXR017 100 assays Ask for price

Caspase-3 Colorimetric Assay Kit - 400 assays

GWB-AXR020 400 assays Ask for price

Caspase-1 Colorimetric Assay Kit - 100 assays

GWB-AXR028 100 assays Ask for price

Caspase-1 Colorimetric Assay Kit - 400 assays

GWB-AXR031 400 assays Ask for price

Caspase-8 Colorimetric Assay Kit - 100 assays

GWB-AXR036 100 assays Ask for price

Caspase-8 Colorimetric Assay Kit - 400 assays

GWB-AXR039 400 assays Ask for price

Caspase-6 Colorimetric Assay Kit - 100 assays

GWB-AXR044 100 assays Ask for price

Caspase-6 Colorimetric Assay Kit - 400 assays

GWB-AXR047 400 assays Ask for price

Caspase-2 Colorimetric Assay Kit - 100 assays

GWB-AXR052 100 assays Ask for price

Caspase-2 Colorimetric Assay Kit - 400 assays

GWB-AXR055 400 assays Ask for price

Caspase-9 Colorimetric Assay Kit - 100 assays

GWB-AXR060 100 assays Ask for price

Caspase-9 Colorimetric Assay Kit - 400 assays

GWB-AXR063 400 assays Ask for price

Caspase-5 Colorimetric Assay Kit - 100 assays

GWB-AXR070 100 assays Ask for price

Caspase-5 Colorimetric Assay Kit - 400 assays

GWB-AXR073 400 assays Ask for price

Caspase-4 Colorimetric Assay Kit - 100 assays

GWB-AXR086 100 assays Ask for price

Caspase-4 Colorimetric Assay Kit - 400 assays

GWB-AXR088 400 assays Ask for price

Caspase-10 Colorimetric Assay Kit - 100 assays

GWB-AXR078 100 assays Ask for price

Caspase-10 Colorimetric Assay Kit - 400 assays

GWB-AXR081 400 assays Ask for price

Caspase-3 Colorimetric Assay Kit - 25 assays

GWB-AXR019 25 assays Ask for price

Caspase-1 Colorimetric Assay Kit - 25 assays

GWB-AXR030 25 assays Ask for price

Caspase-8 Colorimetric Assay Kit - 25 assays

GWB-AXR038 25 assays Ask for price

Caspase-6 Colorimetric Assay Kit - 25 assays

GWB-AXR046 25 assays Ask for price

Caspase-2 Colorimetric Assay Kit - 25 assays

GWB-AXR054 25 assays Ask for price

Caspase-9 Colorimetric Assay Kit - 25 assays

GWB-AXR062 25 assays Ask for price

Caspase-5 Colorimetric Assay Kit - 25 assays

GWB-AXR072 25 assays Ask for price

Caspase-4 Colorimetric Assay Kit - 25 assays

GWB-AXR089 25 assays Ask for price

Caspase-10 Colorimetric Assay Kit - 25 assays

GWB-AXR079 25 assays Ask for price

Nitrite Colorimetric Assay Kit

E-BC-K070-S-100Assays 100 Assays
EUR 150
Description: Quantitative

Nitrite Colorimetric Assay Kit

E-BC-K070-S-50Assays 50 Assays
EUR 12
Description: Quantitative

Nitrite Colorimetric Assay Kit

E-BC-K070-S-each each Ask for price
Description: Quantitative

Multi-Species Nitric Oxide Colorimetric Detection Kit

IMLNOKTC each
EUR 412
Description: Multi-Species Nitric Oxide Colorimetric Detection Kit

OKAU00021-2PLATE - Nitric Oxide Colorimetric Detection Kit

OKAU00021-2PLATE 2plate
EUR 269

Caspase-3 DEVD-R110 Fluorometric and Colorimetric Assay Kit (100 assays)

30008-2 1KIT
EUR 459.6
Description: Minimum order quantity: 1 unit of 1KIT

Caspase-8 IETD-R110 Fluorometric and Colorimetric Assay Kit (100 assays)

30011-2 1KIT
EUR 459.6
Description: Minimum order quantity: 1 unit of 1KIT

Caspase-8 IETD-R110 Fluorometric and Colorimetric Assay Kit (25 assays)

30011-1 1KIT
EUR 244.8
Description: Minimum order quantity: 1 unit of 1KIT

AMP Colorimetric Assay Kit

K229-100 each
EUR 692.4

ATP Colorimetric Assay Kit

E-BC-K157-M-48T 48T
EUR 2
Description: Quantitative

ATP Colorimetric Assay Kit

E-BC-K157-M-96T 96T
EUR 280
Description: Quantitative

ATP Colorimetric Assay Kit

E-BC-K157-M-each each Ask for price
Description: Quantitative

ATP Colorimetric Assay Kit

E-BC-K157-S-100Assays 100 Assays
EUR 280
Description: Quantitative

ATP Colorimetric Assay Kit

E-BC-K157-S-50Assays 50 Assays
EUR 2
Description: Quantitative

ATP Colorimetric Assay Kit

E-BC-K157-S-each each Ask for price
Description: Quantitative

H2S Colorimetric Assay Kit

E-BC-K355-M-48T 48T
EUR 15
Description: Quantitative

H2S Colorimetric Assay Kit

E-BC-K355-M-96T 96T
EUR 220
Description: Quantitative

H2S Colorimetric Assay Kit

E-BC-K355-M-each each Ask for price
Description: Quantitative

Total Oxidant Status -TOS- Colorimetric Assay Kit

E-BC-K802-M-48T 48T
EUR 100
Description: Quantitative

Total Oxidant Status -TOS- Colorimetric Assay Kit

E-BC-K802-M-500Assays 500 Assays
EUR 450
Description: Quantitative

Total Oxidant Status -TOS- Colorimetric Assay Kit

E-BC-K802-M-96T 96T
EUR 15
Description: Quantitative

Iron Colorimetric Assay Kit

K2069-100 100 assays
EUR 547
Description: Detects iron concentration, highly sensitive.

Urea Colorimetric Assay Kit

K375-100 each
EUR 646.8

Heme Colorimetric Assay Kit

K672-100 each
EUR 588

Zinc Colorimetric Assay Kit

K387-100 each
EUR 588

Iron Colorimetric Assay Kit

K390-100 each
EUR 660

HDAC colorimetric assay kit

TBS2065 100 tests
EUR 289

Iron Colorimetric Assay Kit

E-BC-K139-M-48T 48T
EUR 150
Description: Quantitative

Iron Colorimetric Assay Kit

E-BC-K139-M-500Assays 500 Assays
EUR 550
Description: Quantitative

Iron Colorimetric Assay Kit

E-BC-K139-M-96T 96T
EUR 22
Description: Quantitative

Iron Colorimetric Assay Kit

E-BC-K139-S-100Assays 100 Assays
EUR 220
Description: Quantitative

Iron Colorimetric Assay Kit

E-BC-K139-S-50Assays 50 Assays
EUR 15
Description: Quantitative

Iron Colorimetric Assay Kit

E-BC-K139-S-each each Ask for price
Description: Quantitative

PTP1B Colorimetric Assay Kit

30019 96 rxns.
EUR 425
Description: Protein phosphorylation is one of the most important post-translational_x000D_modification processes. Phosphorylation is reversibly regulated by Protein Kinases (PKs) and_x000D_Protein Phosphatases (PTPs). PTP1B (PTPN1) is known to catalyze dephosphorylation of_x000D_insulin receptor kinases and plays a critical role in insulin signaling. The PTP1B Colorimetric_x000D_Assay Kit is designed to measure PTP1B activity for screening and profiling applications, in a_x000D_homogeneous assay with no time-consuming washing steps. The PTP1B Colorimetric Assay Kit is optimized for both_x000D_continuous and end-point assay formats.

Hemin Colorimetric Assay Kit

K2215-100 100 assays
EUR 542
Description: Detects hemin, highly sensitive.

Cytochrome Oxidase Activity Colorimetric Assay Kit

K2020-100 100 assays
EUR 485
Description: Detects cytochrome oxidase activity, high throughput screening (HTS).

Cytochrome Oxidase Activity Colorimetric Assay Kit

K287-100 each
EUR 646.8

Malate Colorimetric Assay Kit

K2139-100 100 assays
EUR 542
Description: Detects malate, accurate.

Malate Colorimetric Assay Kit

K637-100 each
EUR 588

Cobalt Colorimetric Assay Kit

K505-100 each
EUR 548.4

Nickel Colorimetric Assay Kit

K510-100 each
EUR 548.4

Calcium Colorimetric Assay Kit

GWB-AXR220 250 assays Ask for price

Formate Colorimetric Assay Kit

K653-100 each
EUR 698.4

Calcium Colorimetric Assay Kit

K2067-250 250 assays
EUR 427
Description: Detects calcium concentration, sensitive.

Ammonia Colorimetric Assay Kit

K370-100 each
EUR 646.8

Acetate Colorimetric Assay Kit

K2209-100 100 assays
EUR 437
Description: Detects acetate, sensitive.

Calcium Colorimetric Assay Kit

K380-250 each
EUR 516

Acetate Colorimetric Assay Kit

K658-100 each
EUR 614.4

Ethanol Colorimetric Assay kit

TBS2090 100 tests
EUR 259

Formate Colorimetric Assay Kit

E-BC-K1100-M-96T 96T
EUR 400
Description: Quantitative

Formate Colorimetric Assay Kit

E-BC-K1100-M-each each Ask for price
Description: Quantitative

Sucrose Colorimetric Assay Kit

E-BC-K161-S-100Assays 100 Assays
EUR 260
Description: Quantitative

Sucrose Colorimetric Assay Kit

E-BC-K161-S-50Assays 50 Assays
EUR 18
Description: Quantitative

Sucrose Colorimetric Assay Kit

E-BC-K161-S-each each Ask for price
Description: Quantitative

Ethanol Colorimetric Assay Kit

E-BC-K891-M-48T 48T
EUR 260
Description: Quantitative

Ethanol Colorimetric Assay Kit

E-BC-K891-M-500Assays 500 Assays
EUR 1100
Description: Quantitative

Ethanol Colorimetric Assay Kit

E-BC-K891-M-96T 96T
EUR 38
Description: Quantitative

Chitosan Colorimetric Assay Kit

K995-100 each
EUR 679.2

Fumarate Colorimetric Assay Kit

K633-100 each
EUR 614.4

Chloride Colorimetric Assay Kit

K530-100 each
EUR 430.8

Tyrosine Colorimetric Assay Kit

K573-100 each
EUR 660

Fructose Colorimetric Assay Kit

E-BC-K134-S-50Assays 50 Assays
EUR 200
Description: Quantitative

Fructose Colorimetric Assay Kit

E-BC-K134-S-each each Ask for price
Description: Quantitative

Glycerol Colorimetric Assay Kit

E-BC-K340-M-48T 48T
EUR 185
Description: Quantitative

Glycerol Colorimetric Assay Kit

E-BC-K340-M-96T 96T
EUR 280
Description: Quantitative

Glycerol Colorimetric Assay Kit

E-BC-K340-M-each each Ask for price
Description: Quantitative

ADP Colorimetric Assay Kit II

K356-100 each
EUR 686.4

Colorimetric DTT Assay kit

DTT100C 100 assays
EUR 221.78
Description: This product includes 1 ml of 10x Assay buffer, 0.2 ml of 10 x Reagent A, 0.2 ml of 10 x Reagent B and 0.5 ml of 10x Reagent C.

Phosphate Colorimetric Assay Kit

GWB-AXR228 500 assays Ask for price

Glutamate Colorimetric Assay Kit

K629-100 each
EUR 646.8

Magnesium Colorimetric Assay Kit

K2068-100 100 assays
EUR 436
Description: Detects magnesium concentration, sensitive.

Phosphate Colorimetric Assay Kit

k2074-500 500 assays
EUR 245
Description: Detects phosphate, sensitive.

Glutamine Colorimetric Assay Kit

K2084-100 100 assays
EUR 504
Description: Detects glutamine, sensitive.

Glutamate Colorimetric Assay Kit

K2133-100 100 assays
EUR 557
Description: Detects glutamate, simple.

Magnesium Colorimetric Assay Kit

K385-100 each
EUR 574.8

Phosphate Colorimetric Assay Kit

K410-500 each
EUR 379.2

Glutamine Colorimetric Assay Kit

K556-100 each
EUR 705.6

Urea Colorimetric Assay Kit II

K376-100 each
EUR 646.8

Zinc -Zn- Colorimetric Assay Kit

E-BC-K137-M-48T 48T
EUR 150
Description: Quantitative

Zinc -Zn- Colorimetric Assay Kit

E-BC-K137-M-500Assays 500 Assays
EUR 500
Description: Quantitative

Zinc -Zn- Colorimetric Assay Kit

E-BC-K137-M-96T 96T
EUR 22
Description: Quantitative

Zinc Assay Kit (Colorimetric)

MET-5138 100 assays
EUR 410

Hexokinase Colorimetric Assay Kit

K2179-100 100 assays
EUR 538

Hexokinase Colorimetric Assay Kit

K789-100 each
EUR 718.8

Hemoglobin Colorimetric Assay Kit

K219-200 each
EUR 457.2

Isocitrate Colorimetric Assay Kit

K656-100 each
EUR 568.8

Glutathione Colorimetric Assay Kit

55R-1351 100 assays
EUR 567
Description: Assay Kit for detection of Glutathione activity in the research laboratory

Glutathione Colorimetric Assay Kit

K2106-100 100 assays
EUR 466
Description: Detects either total glutathione or exclusively GSH

Glutathione Colorimetric Assay Kit

K261-100 each
EUR 614.4

Sodium -Na- Colorimetric Assay Kit

E-BC-K207-M-48T 48T
EUR 1
Description: Quantitative

Sodium -Na- Colorimetric Assay Kit

E-BC-K207-M-96T 96T
EUR 150
Description: Quantitative

Sodium -Na- Colorimetric Assay Kit

E-BC-K207-M-each each Ask for price
Description: Quantitative

Sodium -Na+- Colorimetric Assay Kit

E-BC-K207-S-200Assays 200Assays
EUR 150
Description: Quantitative

Sodium -Na+- Colorimetric Assay Kit

E-BC-K207-S-each each Ask for price
Description: Quantitative

Copper -Cu- Colorimetric Assay Kit

E-BC-K300-M-48T 48T
EUR 120
Description: Quantitative

Copper -Cu- Colorimetric Assay Kit

E-BC-K300-M-500Assays 500 Assays
EUR 450
Description: Quantitative

Copper -Cu- Colorimetric Assay Kit

E-BC-K300-M-96T 96T
EUR 15
Description: Quantitative

In this research, we present that untimely or an excessive amount of binding of one human protein, cleavage and polyadenylation specificity issue 6 (CPSF6), disrupts the power of the capsid to ship the viral genome to the cell nucleus. Another human protein, cyclophilin A (CypA), can defend HIV capsid from untimely binding to CPSF6, which may differ in CD4+ T cells and macrophages. Better understanding of how HIV infects cells will enable higher medicine to stop or inhibit an infection and pathogenesis.

Minimizing the Impact of the Triple Burden of COVID-19, Tuberculosis and HIV on Health Services in sub-Saharan Africa

Minimizing the Impact of the Triple Burden of COVID-19, Tuberculosis and HIV on Health Services in sub-Saharan Africa

In this angle, we focus on the affect of COVID-19 on tuberculosis (TB)/HIV well being companies and approaches to mitigating the rising burden of these three colliding epidemics in sub-Saharan Africa (SSA). SSA international locations bear considerably excessive proportions of TB and HIV circumstances reported worldwide, in comparison with international locations in the West. Whilst COVID-19 epidemiology seems to range throughout Africa, most international locations in this area have reported comparatively lower-case counts in comparison with the West. Nevertheless, the COVID-19 pandemic has added a further burden to already overstretched well being methods in SSA, which, amongst different issues, have been centered on the longstanding twin epidemics of TB and HIV.

As with these twin epidemics, insufficient sources and poor case identification and reporting could also be contributing to underestimations of the COVID-19 case burden in SSA. Modelling research predict that the pandemic-related disruptions in TB and HIV companies will outcome in vital will increase in related morbidity and mortality over the subsequent 5 years. Furthermore, restricted empirical proof means that SARS-CoV-2 coinfections with TB and HIV are related to elevated mortality threat in SSA. However, predictive fashions require a greater evidence-base to precisely outline the affect of COVID-19, not solely on communicable ailments akin to TB and HIV, however on non-communicable illness comorbidities.

Further analysis is required to evaluate morbidity and mortality knowledge amongst each adults and youngsters throughout the African continent, taking note of geographic disparities, in addition to the medical and socio-economic determinants of COVID-19 in the setting of TB and/or HIV. Big occasions (i.e., distinctive historic disruptions) like the COVID-19 epidemic and its related interval of social distancing can remodel social buildings, social interactions, and social norms.

Social distancing guidelines and the worry of an infection have vastly decreased face-to-face interactions, elevated loneliness, decreased ties to serving to establishments, and can also have disrupted the opioid use behaviors of individuals who use medication. This analysis used Reddit to look at the affect of COVID-19 on the social networks and social processes of individuals who use opioids. The international asymptotic stability of all regular states is confirmed through the use of Lyapunov-LaSalle asymptotic stability theorem.

Mathematical evaluation of an HIV mannequin with latent reservoir, delayed CTL immune response and immune impairment
In this paper, an in-host HIV an infection mannequin with latent reservoir, delayed CTL immune response and immune impairment is investigated. By utilizing appropriate Lyapunov capabilities and LaSalle’s invariance precept, it’s proven that when time delay is the same as zero, the immunity-inactivated copy ratio is a threshold figuring out the international dynamics of the mannequin. A scavenging receptor for LDL-c, LDLr was considerably decreased (0.18-fold) in this group, probably contributing to larger LDL-c ranges. Transcriptional regulator of LDLr, SREBP2 was additionally considerably decrease (0.13-fold) in HIV constructive sufferers.
By means of the persistence idea for infinite dimensional methods, it’s confirmed that if the immunity-inactivated copy ratio is bigger than unity, the mannequin is everlasting. Choosing time delay as the bifurcation parameter and analyzing the corresponding attribute equation of the linearized system, the existence of a Hopf bifurcation at the immunity-activated equilibrium is established. Numerical simulations are carried out for instance the theoretical outcomes and reveal the results of some key parameters on viral dynamics.
This examine sought to guage hepatic expression of key genes in ldl cholesterol metabolism (LDLr, HMGCR, ABCA1) and transcriptional regulators of these genes (microRNA-148a, SREBP2) in HIV constructive sufferers on antiretroviral remedy presenting with gallstones. Liver biopsies from HIV constructive sufferers (circumstances: n = 5) and HIV destructive sufferers (controls: n = 5) have been analysed for miR-148a and mRNA expression utilizing quantitative PCR. Circulating complete ldl cholesterol was elevated in the HIV constructive group with considerably elevated LDL-c ranges(3.16 ± 0.64 mmol/L) relative to uninfected controls (2.10 ± 0.74 mmol/L; p = 0.04). Regulatory microRNA, miR-148a-3p, was decreased in HIV constructive sufferers (0.39-fold) with a concomitant improve in goal ABCA1 (1.5-fold), which regulates ldl cholesterol efflux.
Minimizing the Impact of the Triple Burden of COVID-19, Tuberculosis and HIV on Health Services in sub-Saharan Africa

Stability of HTLV/HIV twin an infection mannequin with mitosis and latency

In this paper, we formulate and analyze an HTLV/HIV twin an infection mannequin taking into account the response of Cytotoxic T lymphocytes (CTLs). The mannequin contains eight compartments, uninfected CD4+T cells, latent HIV-infected cells, lively HIV-infected cells, free HIV particles, HIV-specific CTLs, latent HTLV-infected cells, lively HTLV-infected cells and HTLV-specific CTLs. The HIV can enter and infect an uninfected CD4+T cell by two methods, free-to-cell and infected-to-cell.

Genorise® ADP Colorimetric/Fluorometric Assay Kit

GR107004 100 tests
EUR 350

ATP Colorimetric/Fluorometric Assay Kit

GWB-AXR208 100 assays Ask for price

PEP Colorimetric/Fluorometric Assay Kit

GWB-AXR212 100 assays Ask for price

ATP Colorimetric/Fluorometric Assay Kit

K2040-100 100 assays
EUR 566
Description: Detects ATP, highly sensitive, high throughput screening (HTS).

FAD Colorimetric/Fluorometric Assay Kit

K2042-100 100 assays
EUR 446
Description: Detects FAD, sensitive, high throughput screening (HTS).

PEP Colorimetric/Fluorometric Assay Kit

K365-100 each
EUR 757.2

ATP Colorimetric/Fluorometric Assay Kit

K354-100 each
EUR 698.4

FAD Colorimetric/Fluorometric Assay Kit

K357-100 each
EUR 614.4

ATP Colorimetric/Fluorometric Assay Kit

TBS2010 100 tests
EUR 350

Starch Colorimetric/Fluorometric Assay Kit

K647-100 each
EUR 588

Sucrose Colorimetric/Fluorometric Assay Kit

K626-100 each
EUR 601.2

Maltose Colorimetric/Fluorometric Assay Kit

K628-100 each
EUR 614.4

Alanine Colorimetric/Fluorometric Assay Kit

K652-100 each
EUR 574.8

Lactose Colorimetric/Fluorometric Assay Kit

K624-100 each
EUR 614.4

Ethanol Colorimetric/Fluorometric Assay Kit

K2125-100 100 assays
EUR 586
Description: Detects ethanol, sensitive.

Glucose Colorimetric/Fluorometric Assay Kit

K2091-100 100 assays
EUR 470
Description: Detects glucose, sensitive, high throughput screening (HTS).

Lactate Colorimetric/Fluorometric Assay Kit

K2092-100 100 assays
EUR 568
Description: Detects lactate, sensitive.

Alanine Colorimetric/Fluorometric Assay Kit

K2205-100 100 assays
EUR 436
Description: Detects alanine, sensitive.

Citrate Colorimetric/Fluorometric Assay Kit

K2207-100 100 assays
EUR 498
Description: Detects citrate, sensitive.

Lactose Colorimetric/Fluorometric Assay Kit

K2129-100 100 assays
EUR 542
Description: Detects lactose, sensitive, high throughput screening (HTS).

Maltose Colorimetric/Fluorometric Assay Kit

K2132-100 100 assays
EUR 542
Description: Detects maltose, sensitive.

Ethanol Colorimetric/Fluorometric Assay Kit

K620-100 each
EUR 673.2

Citrate Colorimetric/Fluorometric Assay Kit

K655-100 each
EUR 646.8

Glucose Colorimetric/Fluorometric Assay Kit

K606-100 each
EUR 614.4

Lactate Colorimetric/Fluorometric Assay Kit

K607-100 each
EUR 732

Pyruvate Colorimetric/Fluorometric Assay Kit

K2119-100 100 assays
EUR 600
Description: Detects pyruvate, high throughput screening (HTS).

Fructose Colorimetric/Fluorometric Assay Kit

K2124-100 100 assays
EUR 547
Description: Detects fructose, sensitive, high throughput screening (HTS).

Creatine Colorimetric/Fluorometric Assay Kit

K2137-100 100 assays
EUR 595
Description: Detects creatine, sensitive.

Glycogen Colorimetric/Fluorometric Assay Kit

K2143-100 100 assays
EUR 571
Description: Detects glycogen, sensitive.

Fructose Colorimetric/Fluorometric Assay Kit

K619-100 each
EUR 601.2

Glycogen Colorimetric/Fluorometric Assay Kit

K646-100 each
EUR 732

Creatine Colorimetric/Fluorometric Assay Kit

K635-100 each
EUR 574.8

Pyruvate Colorimetric/Fluorometric Assay Kit

K609-100 each
EUR 732

Galactose Colorimetric/Fluorometric Assay Kit

K2126-100 100 assays
EUR 470
Description: Detects galactose, sensitive, high throughput screening (HTS).

Aspartate Colorimetric/Fluorometric Assay Kit

K2082-100 100 assays
EUR 447
Description: Detects aspartate, sensitive.

Sarcosine Colorimetric/Fluorometric Assay Kit

K2138-100 100 assays
EUR 542
Description: Detects sarcosine, accurate.

Galactose Colorimetric/Fluorometric Assay Kit

K621-100 each
EUR 614.4

Sarcosine Colorimetric/Fluorometric Assay Kit

K636-100 each
EUR 574.8

Aspartate Colorimetric/Fluorometric Assay Kit

K552-100 each
EUR 588

Creatinine Colorimetric/Fluorometric Assay Kit

K625-100 each
EUR 561.6

Creatinine Colorimetric/Fluorometric Assay Kit

K2130-100 100 assays
EUR 470
Description: Detects creatinine, sensitive.

Uric Acid Colorimetric/Fluorometric Assay Kit

K2093-100 100 assays
EUR 498
Description: Detects uric acid, sensitive.

Uric Acid Colorimetric/Fluorometric Assay Kit

K608-100 each
EUR 646.8

Adipogenesis Colorimetric/Fluorometric Assay Kit

K2120-100 100 assays
EUR 403
Description: Detects adipogenesis, highly sensitive.

Oxaloacetate Colorimetric/Fluorometric Assay Kit

K659-100 each
EUR 574.8

Adipogenesis Colorimetric/Fluorometric Assay Kit

K610-100 each
EUR 516

Free Glycerol Colorimetric/Fluorometric Assay Kit

K630-100 each
EUR 633.6

Ascorbic Acid Colorimetric/Fluorometric Assay Kit

K661-100 each
EUR 588

Ascorbic Acid Colorimetric/Fluorometric Assay Kit

K2211-100 100 assays
EUR 447
Description: Detects ascorbic acid, sensitive.

Free Glycerol Colorimetric/Fluorometric Assay Kit

K2134-100 100 assays
EUR 605
Description: Detects free glycerol, sensitive.

L-Carnitine Colorimetric/Fluorometric Assay Kit

K2142-100 100 assays
EUR 638
Description: Detects L-carnitine, simple.

L-Carnitine Colorimetric/Fluorometric Assay Kit

K642-100 each
EUR 718.8

Lactic Acid Assay, Colorimetric/Fluorometric Assay

TBS2071-100 100 tests
EUR 320

Phosphatidylcholine Colorimetric/Fluorometric Assay Kit

K2086-100 100 assays
EUR 447
Description: Detects phosphatidylcholine, sensitive.

Phosphatidylcholine Colorimetric/Fluorometric Assay Kit

K576-100 each
EUR 588

Phospholipid Assay Kit (Colorimetric/Fluorometric)

K351-100 each
EUR 660

Enolase Activity Colorimetric/Fluorometric Assay Kit

K691-100 each
EUR 952.8

Genorise® ATP Colorimetric/Fluorometric Assay Kit

GR107002 100 tests
EUR 350

Coenzyme A (CoA) Colorimetric/Fluorometric Assay Kit

K367-100 each
EUR 614.4

Catalase Activity Colorimetric/Fluorometric Assay Kit

K2177-100 100 assays
EUR 427
Description: Highly Sensitive Assay, HTS

Catalase Activity Colorimetric/Fluorometric Assay Kit

K773-100 each
EUR 502.8

Hydrogen Peroxide Colorimetric/Fluorometric Assay Kit

K265-200 each
EUR 457.2

Sialic Acid (NANA) Colorimetric/Fluorometric Assay Kit

K566-100 each
EUR 660

Peroxidase Activity Colorimetric/Fluorometric Assay Kit

K772-100 each
EUR 464.4

Lipolysis (Adipocyte) Colorimetric/Fluorometric Assay Kit

K581-5 each
EUR 790.8

2-Phosphoglycerate Colorimetric/Fluorometric Assay Kit

K778-100 each
EUR 738

Glucose and Sucrose Colorimetric/Fluorometric Assay Kit

K616-100 each
EUR 646.8

Maltose and Glucose Colorimetric/Fluorometric Assay Kit

K618-100 each
EUR 633.6

Alpha-Ketoglutarate Colorimetric/Fluorometric Assay Kit

K2216-100 100 assays
EUR 557
Description: Detects alpha-ketoglutarate, highly sensitive.

Asparaginase Activity Colorimetric/Fluorometric Assay Kit

K754-100 each
EUR 660

Alpha-Ketoglutarate Colorimetric/Fluorometric Assay Kit

K677-100 each
EUR 646.8

Xanthine/Hypoxanthine Colorimetric/Fluorometric Assay Kit

K685-100 each
EUR 502.8

Galactose and Lactose Colorimetric/Fluorometric Assay Kit

K617-100 each
EUR 646.8

Lipid Peroxidation (MDA) Colorimetric/Fluorometric Assay Kit

K2167-100 100 assays
EUR 605
Description: Sensitive, Colorimetric & Fluorometric Assay

Lipid Peroxidation (MDA) Colorimetric/Fluorometric Assay Kit

K739-100 each
EUR 698.4

Pyruvate Kinase Activity Colorimetric/Fluorometric Assay Kit

K709-100 each
EUR 732

Glucose Oxidase Activity Colorimetric/Fluorometric Assay Kit

K788-100 each
EUR 646.8

Pyruvate Kinase Activity Colorimetric/Fluorometric Assay Kit

K2223-100 100 assays
EUR 643
Description: Detects pyruvate kinase activity, sensitive, high throughput screening (HTS).

Xanthine Oxidase Activity Colorimetric/Fluorometric Assay Kit

K2224-100 100 assays
EUR 427
Description: Detects xanthine oxidase activity, sensitive.

Xanthine Oxidase Activity Colorimetric/Fluorometric Assay Kit

K710-100 each
EUR 489.6

Lysophosphatidylcholine Assay Kit (Colorimetric/Fluorometric)

K735-100 each
EUR 732

Glycerophosphorylcholine Assay Kit (Colorimetric/Fluorometric)

K433-100 each
EUR 679.2

Pyrophosphate (PPi) Assay Kit (Fluorometric/Colorimetric)

K568-100 each
EUR 561.6

Adenylate Kinase (AK) Activity Assay Kit (Colorimetric/Fluorometric)

K350-100 each
EUR 646.8

Fast Glucose Determination Assay (Colorimetric/Fluorometric)

TBS2087-200 200 tests
EUR 269

Fast Glucose Determination Assay (Colorimetric/Fluorometric)

TBS2087-600 600 tests
EUR 660

Total Cholesterol and Cholesteryl Ester Colorimetric/Fluorometric Assay Kit

K2090-100 100 assays
EUR 509
Description: Detects total cholesterol and cholesteryl ester, sensitive.

Total Cholesterol and Cholesteryl Ester Colorimetric/Fluorometric Assay Kit

K603-100 each
EUR 660

CytoSelect™ 24-well Anoikis Assay (Colorimetric/Fluorometric)

CBA-080 24 assays
EUR 505

CytoSelect™ 96-well Anoikis Assay (Colorimetric/Fluorometric)

CBA-081 96 assays
EUR 525

Caspase-3 DEVD-R110 Fluorometric and Colorimetric Assay Kit (100 assays)

30008-2 1KIT
EUR 459.6
Description: Minimum order quantity: 1 unit of 1KIT

Caspase-8 IETD-R110 Fluorometric and Colorimetric Assay Kit (100 assays)

30011-2 1KIT
EUR 459.6
Description: Minimum order quantity: 1 unit of 1KIT

Alanine Aminotransferase (ALT or SGPT) Activity Colorimetric/Fluorometric Assay Kit

K2170-100 100 assays
EUR 491
Description: Sensitive Assay, HTS

Alanine Aminotransferase (ALT or SGPT) Activity Colorimetric/Fluorometric Assay Kit

K752-100 each
EUR 639.6

Caspase-8 IETD-R110 Fluorometric and Colorimetric Assay Kit (25 assays)

30011-1 1KIT
EUR 244.8
Description: Minimum order quantity: 1 unit of 1KIT

Fast Glucose Oxidase Determination Assay (Colorimetric/Fluorometric)

TBS2088-200 200 tests
EUR 269

Fast Glucose Oxidase Determination Assay (Colorimetric/Fluorometric)

TBS2088-600 600 tests
EUR 660

PPDK (Pyruvate, phosphate dikinase) Activity Assay Kit (Fluorometric/Colorimetric)

K456-100 each
EUR 574.8

Glycerol Colorimetric / Fluorometric Assy

TBS2204 100 tests
EUR 320

Triglyceride Quantification Colorimetric/Fluorometric Kit

K2127-100 100 assays
EUR 629
Description: Detects triglyceride, sensitive.

Triglyceride Quantification Colorimetric/Fluorometric Kit

K622-100 each
EUR 744

L-Amino Acid Quantitation Colorimetric/Fluorometric Kit

K639-100 each
EUR 574.8

L-Amino Acid Quantitation Colorimetric/Fluorometric Kit

K2141-100 100 assays
EUR 436
Description: Detects L-amino acid, sensitive.

Free Fatty Acid Quantification Colorimetric/Fluorometric Kit

K2121-100 100 assays
EUR 624
Description: Detects free fatty acid, sensitive.

Free Fatty Acid Quantification Colorimetric/Fluorometric Kit

K612-100 each
EUR 732

HDL and LDL/VLDL Quantification Colorimetric/Fluorometric Kit

K2122-100 100 assays
EUR 667
Description: Detects HDL and LDL/VLDL, sensitive.

HDL and LDL/VLDL Quantification Colorimetric/Fluorometric Kit

K613-100 each
EUR 783.6

Choline/Acetylcholine Quantification Colorimetric/Fluorometric Kit

K2123-100 100 assays
EUR 523
Description: Detects choline/acetylcholine, highly sensitive.

Choline/Acetylcholine Quantification Colorimetric/Fluorometric Kit

K615-100 each
EUR 673.2

PicoProbe? ADP Assay Kit (Fluorometric)

K211-100 each
EUR 698.4

ADP Colorimetric Assay Kit II

K356-100 each
EUR 686.4

GST Fluorometric Assay Kit

55R-1350 100 assays
EUR 513
Description: Assay Kit for detection of GST activity in the research laboratory

NADH Fluorometric Assay Kit

K2037-100 100 assays
EUR 557
Description: Detects NADH, highly sensitive.

HDAC Fluorometric Assay kit

TBS2060 100 tests
EUR 289

Glucose Fluorometric Assay Kit

K2221-100 100 assays
EUR 571
Description: Detects glucose, highly sensitive, high throughput screening (HTS).

Lactate Fluorometric Assay Kit

K2140-100 100 assays
EUR 586
Description: Detects lactate, highly sensitive, high throughput screening (HTS).

Inosine Fluorometric Assay Kit

K712-100 each
EUR 639.6

Ethanol Fluorometric Assay kit

TBS2095 100 tests
EUR 259

Sucrose Fluorometric Assay Kit

E-BC-F042-96T 96T
EUR 350
Description: Quantitative

Sucrose Fluorometric Assay Kit

E-BC-F042-each each Ask for price
Description: Quantitative

Glycogen Fluorometric Assay Kit

E-BC-F040-500Assays 500 Assays
EUR 1000
Description: Quantitative

Glycogen Fluorometric Assay Kit

E-BC-F040-96T 96T
EUR 425
Description: Quantitative

Glycogen Fluorometric Assay Kit

E-BC-F040-each each Ask for price
Description: Quantitative

Phosphate Fluorometric Assay Kit

55R-1404 100 assays
EUR 367
Description: Assay Kit for detection of Phosphate in the research laboratory

Phosphate Fluorometric Assay Kit

GWB-AXR232 100 assays Ask for price

Citrulline Fluorometric Assay Kit

K2002-100 each
EUR 744

Glutathione Fluorometric Assay Kit

K2098-100 100 assays
EUR 595
Description: Simple assay to detect total glutathione

Glutathione Fluorometric Assay Kit

K251-100 each
EUR 574.8

Zinc Assay Kit (Fluorometric)

K428-100 each
EUR 627.6

Triglyceride Fluorometric Assay Kit

E-BC-F033-48T 48T
EUR 356
Description: Quantitative

Triglyceride Fluorometric Assay Kit

E-BC-F033-96T 96T
EUR 520
Description: Quantitative

Triglyceride Fluorometric Assay Kit

E-BC-F033-each each Ask for price
Description: Quantitative

Adipogenesis Fluorometric Assay Kit

E-BC-F065-96T 96T
EUR 350
Description: Quantitative

Adipogenesis Fluorometric Assay Kit

E-BC-F065-each each Ask for price
Description: Quantitative

Phenylalanine Fluorometric Assay Kit

K572-100 each
EUR 574.8

Caspase 3 Fluorometric Assay Kit

55R-1269 25 assays
EUR 527
Description: Assay Kit for detection of Capase 3 activity in the research laboratory

Caspase 1 Fluorometric Assay Kit

55R-1272 25 assays
EUR 527
Description: Assay Kit for detection of Capase 1 activity in the research laboratory

Caspase 8 Fluorometric Assay Kit

55R-1274 25 assays
EUR 527
Description: Assay Kit for detection of Capase 8 activity in the research laboratory

Caspase 6 Fluorometric Assay Kit

55R-1276 25 assays
EUR 467
Description: Assay Kit for detection of Capase 6 activity in the research laboratory

Caspase 2 Fluorometric Assay Kit

55R-1278 25 assays
EUR 507
Description: Assay Kit for detection of Capase 2 activity in the research laboratory

Caspase 9 Fluorometric Assay Kit

55R-1280 25 assays
EUR 513
Description: Assay Kit for detection of Capase 9 activity in the research laboratory

Caspase 5 Fluorometric Assay Kit

55R-1282 25 assays
EUR 473
Description: Assay Kit for detection of Capase 5 activity in the research laboratory

Caspase 10 Fluorometric Assay Kit

55R-1284 25 assays
EUR 507
Description: Assay Kit for detection of Capase 10 activity in the research laboratory

Caspase 4 Fluorometric Assay Kit

55R-1286 25 assays
EUR 513
Description: Assay Kit for detection of Capase 4 activity in the research laboratory

Starch Assay Kit (Fluorometric)

MET-5026 100 assays
EUR 410

Malate Assay Kit (Fluorometric)

MET-5120 100 assays
EUR 395

Lysine Assay Kit (Fluorometric)

MET-5129 100 assays
EUR 525

Caspase-3 Fluorometric Assay Kit

K2007-100 100 assays
EUR 322
Description: Detects DEVD-dependent caspase activity, highly-sensitive.

Caspase-3 Fluorometric Assay Kit

K2007-200 200 assays
EUR 469
Description: Detects DEVD-dependent caspase activity, highly-sensitive.

Caspase-3 Fluorometric Assay Kit

K2007-25 25 assays
EUR 143
Description: Detects DEVD-dependent caspase activity, highly-sensitive.

Caspase-3 Fluorometric Assay Kit

K2007-400 400 assays
EUR 789
Description: Detects DEVD-dependent caspase activity, highly-sensitive.

Caspase-1 Fluorometric Assay Kit

K2010-100 100 assays
EUR 586
Description: Detects YVAD-dependent caspase activity, highly-sensitive.

Caspase-1 Fluorometric Assay Kit

K2010-200 200 assays
EUR 835.2

Caspase-1 Fluorometric Assay Kit

K2010-25 25 assays
EUR 285.6

Infected-to-cell unfold of HIV happens when uninfected CD4+T cells are touched with lively or latent HIV-infected cells. In distinction, there are two modes for HTLV-I transmission, (ⅰ) horizontal, through direct infected-to-cell contact, and (ⅱ) vertical, by mitotic division of lively HTLV-infected cells. We analyze the mannequin by proving the nonnegativity and boundedness of the options, calculating all attainable regular states, deriving a set of key threshold parameters, and proving the international stability of all regular states.We carried out numerical simulations to help and illustrate the theoretical outcomes. In addition, we in contrast between the dynamics of single and twin infections.

Antibodies For In Vivo Research

The use of antibodies for in vivo research and the development of functional studies considerably expand the scope of immunoglobulins beyond in vitro immunoassays .

In in vivo studies , the antibodies can be used on living cells or in whole animals by injection, with the aim of depleting a certain cell type, blocking receptors or inducing cellular activation to carry out functional studies.

Antibodies for in vivo research are generally monoclonal in type, are produced in bulk (bulk) quantities from hybridomas, and are thoroughly purified to remove potential remains of cell culture reagents and other potential contaminants that may interfere with preclinical assays.

Characteristics Of Antibodies For In Vivo Research

As we have said, in vivo research requires the application of antibodies directly to living organisms. For this reason, these reagents must meet certain specifications that are not usually common in antibodies for in vitro immunoassays such as ELISA , Western Blot , Immunohistochemistry or flow cytometry, among others.

The specifications to be met by antibodies for in vivo research include:

  • Very low endotoxin level (<2 EU / mg)
  • High purity (> 95%)
  • Be free of murine pathogens
  • Azide free
  • Free of compounds that can interfere in in vivo tests , such as preservatives, stabilizers, etc.
  • Presented in high concentrations (˃1mg / ml)

In conclusion, antibodies are fundamental reagents for biomedical research, not only in in vitro immunoassays , but also for conducting in vivo studies and functional assays. Their high sensitivity and specificity, their relatively easy production and the flexibility in the applications in which they can be used, make these reagents invaluable tools.