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Caribbean and Central and South America - CCASAnet

Daniel Masys, Principal Investigator
Vanderbilt University, Biomedical Informatics
Nashville, Tennessee, USA

http://ccasanet.vanderbilt.edu

The Caribbean, Central and South America network for HIV epidemiology (CCASAnet) brings together the clinical and data expertise and resources of Vanderbilt University and clinical sites in Argentina, Brazil, Chile, Haiti, Honduras and Peru.  CCASAnet will use state-of-the-art technologies to create a shared data repository and associated methods for data merging that forms the union of existing HIV-related clinical data sets available at the participating sites.  The project will conduct and facilitate research using the shared data repository that enables answers to questions that cannot be answered by any single source, and develop and evaluate new biostatistical methods relevant to HIV epidemiology.

CCASAnet will develop and conduct a program of face-to-face and educational and training based on International Good Clinical Practice standards that will assist sites to improve the quality and consistency of their clinical research activities.  The CCASAnet Coordinating Center will provide infrastructure for review and approval of data use requests, create end-user data access tools that facilitate research using the shared data repository, and assist investigators with analysis and publication of research findings.  CCASAnet will also participate with other regional IeDEA networks in the development of international standards for sharing and meta-analysis of HIV-related data.  By these activities, CCASAnet will help advance both the science of HIV epidemiology, and the information science that underpins international research collaboration.

Regional Publications

An XML model of an enhanced data dictionary to facilitate the exchange of pre-existing clinical research data in international studies.
Duda SN, Cushman C, Masys DR.
Source: Stud Health Technol Inform. 2007;129(Pt 1):449-53.


Cohort Profile: Caribbean, Central and South America Network for HIV research (CCASAnet) collaboration within the International Epidemiologic Databases to Evaluate AIDS (IeDEA) programme.
McGowan CC, Cahn P, Gotuzzo E, Padgett D, Pape JW, Wolff M, Schechter M, Masys DR.
Int J Epidemiol. 2007 Oct;36(5):969-76


Electronic medical record systems, data quality and loss to follow-up: survey of antiretroviral therapy programmes in resource-limited settings.
Forster, M
Bull World Health Organ. 2008, 86 (12): 939-947.


Mortality during the first year of potent antiretroviral therapy in HIV-1-infected patients from 5 treatment centers in the Caribbean and Latin America
S. Tuboi, B. Shepherd, C. Cesar, A. Krolewiecki, P. Cahn, M. Wolff, J. Pape, E. Gotuzzo, M. Bacon, C. McGowan, D. Masys, M. Schechter.
XVII International AIDS Conference, Mexico City, 3-8 August, 2008. [Abstract MOAB02]


Mortality During the First Year of Potent Antiretroviral Therapy in HIV-1-Infected Patients in 7 Sites Throughout Latin America and the Caribbean
Tuboi SH, Schechter M, McGowan CC, Cesar C, Krolewiecki A, Cahn P, Wolff M, Pape JW, Padgett D, Madero JS, Gotuzzo E, Masys DR, Shepherd BE
J Acquir Immune Defic Syndr. 2009 May 6


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